Recurrent localised inflammatory skin reactions healing with hyperpigmentation can be induced by certain drugs and are known as fixed drug eruptions. In few cases also food was described to induce these symptoms, and the term " fixed food eruptions " was coined. Fixed food eruptions are rare, the first case was reported in 1992 (1) and the term in analogy to the clinical similarities to fixed d...

Gingival hyperpigmentation and the condition known as gummy smile are very common dental cosmetic problems. Gingival hyperpigmentation arises due to the excess presence of melanin in certain regions of the gums. In the case of gummy smile, more than the required amount of gingival tissue is exposed upon smiling. An aesthetically pleasing smile should expose only a negligible amount of gingival ...

A 55-year-old white woman receiving peginterferon alfa2a (180 mg) and ribavirin (1200 mg) combination therapy for hepatitis C virus (HCV; genotype 1b) infection complained of a burning sensation and discomfort in her tongue in the second month, and tongue hyperpigmentation in the fourth month of the therapy. Physical examination revealed hyperpigmentation on the lateral and dorsal parts of the ...

Cutaneous hyperpigmentation may be caused by a number of diseases, such as Addison’s disease, scleroderma, haemochromatosis, Peutz-Jeghers syndrome, lichen planus, and adverse reactions to some medications such as oral contraceptives, cyclophosphamide, chloroquine, minocycline, bleomycin, ketoconazole and methyldopa (1). Hyperpigmentation of the tongue, face and body skin is a rare adverse effe...

The author provides his perspective on resurfacing procedures in dark-skinned patients, advising a cautious approach to laser resurfacing. Laser complications in Fitzpatrick skin types III to VI, including hyperpigmentation, hypopigmentation, and scarring, are well documented. Unlike chemical peeling and dermabrasion, with laser resurfacing, preoperative treatment does not control postoperative...

Bleomycin is a chemotherapeutic agent used in the treatment of different tumours. It has several side effects, including flagellate hyperpigmentation, which is a unique and a well-documented side effect of bleomycin therapy. We report a case of a 23-year-old woman with a personal history of ovarian dysgerminoma, who developed flagellate hyperpigmentation on trunk after bleomycin therapy.

Sir, Mucocutaneous side effects associated with bleomycin are stomatitis, ulcers, scaly erythematous and bullous lesions, sclerosis, nail changes, digital gangrene and pigmentary alterations. Hyperpigmentation occurring mainly on the pressure areas of the skin as well as in areas of scratch marks is seen in approximately 30% of patients. Flagellate hyperpigmentation is very characteristic of bl...

Skin hyperpigmentation is characterized as increased production and accumulation of melanin, which could be aesthetically unfavorable and develops serious skin diseases. There is a need to find new depigmenting agents, since many current natural and synthetic products present undesired side effects. In Iranian traditional medicine (ITM), plants have been used for the treatment of skin diseases ...

BACKGROUND Many clinicians have used glycolic acid (GA) peels for facial acne, scarring, and hyperpigmentation, mainly in lighter skin types. Salicylic-mandelic acid combination peels (SMPs) are a newer modality, and there have been no well-controlled studies comparing them with other conventional agents. OBJECTIVE To compare the therapeutic efficacy and tolerability of 35% GA peels and 20% s...

INTRODUCTION Familial glucocorticoid deficiency, or hereditary unresponsiveness to adrenocorticotropic hormone, is a rare autosomal recessive disease characterized by glucocorticoid deficiency in the absence of mineralocorticoid deficiency. It may present in infancy or early childhood with hyperpigmentation, failure to thrive, recurrent infections, hypoglycemic attacks and convulsions that may ...