نتایج جستجو برای: inflammatory diseases

تعداد نتایج: 1034652  

Journal: :مجله علوم اعصاب شفای خاتم 0
safieh ebrahimi department of medical biochemistry, school of medicine, mashhad university of medical sciences, mashhad, iran mohammad jalili-nik department of medical biochemistry, school of medicine, mashhad university of medical sciences, mashhad, iran hossein abde-ahad department of medical biochemistry, school of medicine, mashhad university of medical sciences, mashhad, iran mahdi hassanian department of medical biochemistry, school of medicine, mashhad university of medical sciences, mashhad, iran

thrombin is a multifunctional enzyme which has key roles in coagulation cascade and inflammatory events. the pro-inflammatory functions of thrombin occur by different mechanisms including increasing mast cell degranulation, up-regulating the expression of cell adhesion molecules (cams) and promoting the secretion of inflammatory chemokines and cytokines. dysregulated signaling functions of thro...

Hossein Abde-Ahad, Mahdi Hassanian, Mohammad Jalili-Nik, Safieh Ebrahimi,

Thrombin is a multifunctional enzyme which has key roles in coagulation cascade and inflammatory events. The pro-inflammatory functions of thrombin occur by different mechanisms including increasing mast cell degranulation, up-regulating the expression of cell adhesion molecules (CAMs) and promoting the secretion of inflammatory chemokines and cytokines. Dysregulated signaling functions of thro...

Ameneh Khoshvaghti Amir Vafafar Hamid reza Gheisari Saied Nazifi

This study was designed to evaluate serum and milk haptoglobin (Hp) as an inflammatory indicators for the diagnosis of diseases in cattle in Fars province of Iran. Blood samples were collected from the coccygeal vein of 20 clinically healthy cattle and 100 cows with various inflammatory diseases. There were significant differences in serum and milk Hp between clinically healthy cattle and disea...

Journal: :مجله علوم اعصاب شفای خاتم 0
sara abbassi student research committee, faculty of medicine, mashhad university of medical sciences, mashhad, iran

multiple sclerosis (ms) is the most common autoimmune disease, especially among young’s. neuroinflammation results from inflammation in cns and it may cause different disorders and diseases .it is also known as a detriment in multiple sclerosis. in fact, it causes problems and symptoms in ms. in ms the self-immune cells attack the myelin of neurons, it maybe the nerve in brain or spinal cord. d...

2010
Masakazu Nagahori

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan 󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏 Our understanding of IBD pathogenesis has been increasing rapidly. The genetically determined interplay between the commensal microbiota, intestinal epithelial cells, and the immune ...

Journal: :Gastroenterology 2015
Dermot P B McGovern Subra Kugathasan Judy H Cho

In this review, we provide an update on genome-wide association studies (GWAS) in inflammatory bowel disease (IBD). In addition, we summarize progress in defining the functional consequences of associated alleles for coding and noncoding genetic variation. In the small minority of loci where major association signals correspond to nonsynonymous variation, we summarize studies defining their fun...

2012
Yutao Yan

Ulcerative colitis (UC) and Crohn’s disease (CD), collectively called inflammatory bowel disease (IBD), are idiopathic, chronic, and relapsing intestinal inflammatory disorder, characterized by abdominal pain and diarrhea. UC differs dramatically from CD with the respects of disease distribution, morphology, and histopathology; for example, CD can affect any part of the gastrointestinal (GI) tr...

2014
Thea K. Wöbke Bernd L. Sorg Dieter Steinhilber

Changes in vitamin D serum levels have been associated with inflammatory diseases, such as inflammatory bowel disease (IBD), rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis (MS), atherosclerosis, or asthma. Genome- and transcriptome-wide studies indicate that vitamin D signaling modulates many inflammatory responses on several levels. This includes (i) the regulation of t...

Journal: :Digestive diseases 2010
Raja Atreya M F Neurath

Uncontrolled activation of mucosal effector cells has been identified as the main pathogenic mechanism involved in the initiation and perpetuation of mucosal inflammation in inflammatory bowel diseases (IBD). The sustained activation of these cells leads to the aberrant production of various pro-inflammatory mediators, which co-ordinated action amplifies the inflammatory process. In this settin...

2014
Hung-Chen Wang Cheng-Hsien Lu Kuang-I Cheng Jason Cheng-Hsuan Chiang

1Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan 2Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan 3Department of Biological Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan 4Department of Anesthesiology, Kaohsiung Medical University Hospital, Kaohsiung...

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