The cell transition from an inflammatory phase to a subsequent proliferative is crucial for wound healing; however, the mechanism driving this not well understood. By profiling lncRNA expression changes during human skin healing and screening functions, we identified SNHG26, conserved upregulated healing, as pivotal regulator in keratinocyte progenitor cells underpinning transition.Snhg26-defic...

Abstract Particulate matter (PM) aggravates airway and lung inflammatory response in allergic asthma by directly inducing Th17 cells to secrete cell-associated factors chemokines. IL-17A is a key cell secretion pro-inflammatory cytokine. In this study, we investigated the role of PM-induced mice. 7–8 weeks old wild type (WT) mice, similarly knockout (KO) were divided into four experimental grou...

Sepsis is a life-threatening organ dysfunction caused by disturbed response to infection. The development of sepsis preceded Systemic Inflammatory Response Syndrome (SIRS), which the overall inflammatory body severe lesion. role opportunistic pathogens in CER and may be considered proven, but value intestinal microbiome remains underestimated. survey systematized data on cell wall or membrane c...

glutamate-mediated excitotoxicity and neurodegeneration have been shown as pathophysiological hallmarks of multiple sclerosis (ms) and other autoimmune inflammatory cns disorders. n‑methyl‑d‑aspartate (nmda) receptors play a pivotal role in the mediation of neuronal glutamate excitotoxicity leading to cellular damage and apoptotic cell death. current treatment approaches targeting glutamate exc...

multiple sclerosis is an autoimmune cns-disease characterized by inflammatory neurodegenerative events occurring with de- and remyelination. recent evidence show that demyelinated neurons are less excitable than myelinated ones while at early stages of remyelination these neurons seem to be hyperexcitable. the latter is a transitory condition that, very likely, leads to impaired neuronal networ...

Objective(s): Fluvoxamine is a well-known selective serotonin reuptake inhibitor (SSRI); Despite its anti-inflammatory effect, little is known about the precise mechanisms involved. In our previous work, we found that IP administration of fluvoxamine produced a noticeable anti-inflammatory effect in carrageenan-induced paw edema in rats. In this study, we aimed to evaluate the effect of fluvoxa...

As in Iranian traditional medicine, bee venom (BV) is a promising treatment for the rheumatoid arthritis (RA) which is considered as a problematic human chronic inflammatory disease in the present time. Smoking is considered to be a major risk factor in RA onset and severity. The main aim of this study is to investigate the effects of BV on cigarette smoke-induced inflammatory response in fibro...

As in Iranian traditional medicine, bee venom (BV) is a promising treatment for the rheumatoid arthritis (RA) which is considered as a problematic human chronic inflammatory disease in the present time. Smoking is considered to be a major risk factor in RA onset and severity. The main aim of this study is to investigate the effects of BV on cigarette smoke-induced inflammatory response in fibro...

Objective(s): Inflammation is an immune response toward injuries. Although inflammation is healing response, but in some condition it will lead to chronic disease such as rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, Alzheimer’s and various cancer. Indonesian cassia (Cinnamomum burmanni C. Nees & T. Ness) known to contain coumarin, is widely used for alternative medicine es...