oral contraceptive pills have several side effects especially on the gastrointestinal tract and liver. absorption of low dose (ld) pills by the vaginal route avoids the first pass of the steroids through these tracts and probably has fewer side effects. this study was a cohort study for evaluation of side effects and acceptability of ld pills administered by the vaginal route. in a clinical tri...

Attempts to detect infectivity in the blood of humans and animals affected with transmissible spongiform encephalopathies (TSEs or prion diseases) have often been inconclusive because of the limitations of cross-species bioassays and the small volumes of blood that can be injected by the intracerebral route. A model has been developed for the experimental study of TSE transmission by blood tran...

Cancer is a devastating disease and a large socio-economic burden. Novel therapeutic solutions are on the rise, although a cure remains elusive. Application of microorganisms represents an ancient therapeutic strategy, lately revoked and refined via simultaneous attenuation and amelioration of pathogenic properties. Salmonella Typhimurium has prevailed in preclinical development. Yet, using vir...

Initially HIV infection in Arad County was impacting infant population. Later most of the new cases were adults, but even so trends in recent years are moving in the same way for adults and children, the latter being infected through vertical transmission. The hypothesis was to determine the relationship between age of cases at diagnosis moment and route of transmission in more than two decades...

Across the placenta infections include Toxoplasma gondii, Treponema pallidum, Listeria monocytogenes, Plasmodium falciparum (malaria), rubella and cytomegalovirus (CMV). Ascending maternal infection and chorioamnionitis causing fetal infection, usually subsequent to prolonged rupture of membranes. Perinatal infection acquired during birth via the haematogenous or genital route. These include hu...

Across the placenta infections include Toxoplasma gondii, Treponema pallidum, Listeria monocytogenes, Plasmodium falciparum (malaria), rubella and cytomegalovirus (CMV). Ascending maternal infection and chorioamnionitis causing fetal infection, usually subsequent to prolonged rupture of membranes. Perinatal infection acquired during birth via the haematogenous or genital route. These include hu...

The long-term spontaneous evolution of humans and the human immunodeficiency virus (HIV) is not well characterized; many vertebrate species, including humans, exhibit remnants of other retroviruses in their genomes that question such possible endogenization of HIV. We investigated two HIV-infected patients with no HIV-related disease and no detection with routine tests of plasma HIV RNA or cell...

1. The experiments given in this paper, notwithstanding their seeming diversity, relate to the conditions underlying the states of susceptibility and refractoriness to infection with the virus of poliomyelitis applied to the nasal mucosa. 2. Certain monkeys are highly refractory to inoculation via the nares with the virus of poliomyelitis, apparently in virtue of a power possessed by the nasal ...