AIMS Tailored heart failure treatment and risk assessment in patients following ST-segment elevation myocardial infarction (STEMI) is mainly based on the assessment of the left ventricular (LV) ejection fraction (EF). Assessment of the final infarct size in addition to the LVEF may improve the prognostic evaluation. To evaluate the prognostic importance of the final infarct size measured by car...

BACKGROUND AND OBJECTIVES We sought to investigate the relationship between levels of high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and the infarct size and left ventricular (LV) volume after acute myocardial infarction (MI). SUBJECTS AND METHODS Eighty-six patients with acute ST-elevation MI underwent delayed enhancement multidetector ...

See article by de Groot et al. [9] (pages 315 –324) in this limitation of enzymatic infarct size [7]. Earlier, we demonissue. strated that thrombolytic therapy had no influence on the relation between infarct size estimated with aHBDH and Although the use of biochemical markers of acute left ventricular performance, indicating that coronary remyocardial infarction started in 1954 [1], their val...

The β1-adrenergic-receptor (ADRB1) antagonist metoprolol reduces infarct size in acute myocardial infarction (AMI) patients. The prevailing view has been that metoprolol acts mainly on cardiomyocytes. Here, we demonstrate that metoprolol reduces reperfusion injury by targeting the haematopoietic compartment. Metoprolol inhibits neutrophil migration in an ADRB1-dependent manner. Metoprolol acts ...

Background Exposure to environmental tobacco smoke (ETS) has been epidemiologically linked to death from ischemic heart disease in nonsmokers. In this study, we evaluated the influence of 3 days, 3 weeks, and 6 weeks of ETS exposure on myocardial infarct size in a rat ischemia/reperfusion model. Methods and Results Sprague-Dawley rats exposed to ETS (four Marlboro cigarettes per 15 minutes, 6 h...

Ticagrelor (Brilinta; AstraZeneca Pharmaceuticals LP, Wilmington, DE, USA) is a direct acting, reversible, oral P2Y12 inhibitor.1) In the PLATelet inhibition and patient Outcomes (PLATO) study, compared to clopidogrel (Plavix; Bristol-Myers Squibb/Sanofi Pharmaceuticals, Bridgewater, NJ, USA), ticagrelor reduced the rate of death from vascular causes, myocardial infarction (MI), or stroke in pa...

BACKGROUND Although ejection fraction (EF) both perimyocardial infarction (MI) and late post-MI are important prognostic factors, only implantable cardioverter-defibrillator trials of post-MI patients with depressed late EF have shown improved survival. This may relate to imprecision of early EF because of post-MI stunning. We sought to determine if peri-MI infarct size, as measured by cardiac ...

BACKGROUND 17 beta-estradiol reduces myocardial infarct size which is mediated by nitric oxide (NO) and the opening of Ca (2+)-activated K+ (KCa) channels. Raloxifene, a selective estrogen receptor modulator, demonstrates acute coronary artery vasorelaxing effects. Whether raloxifene reduces ischemia/reperfusion injury and what mechanisms are involved in the cardioprotective effects were invest...

Purpose LV volumetry and infarct size measurement using cardiac magnetic resonance imaging (MRI) is the reference standard to non-invasively measure and to quantify cardiac volumes, function and infarct size. We have observed a high variability of cardiac MRI measurements, if inexperienced observers evaluated the MRI data. The purpose of the study was to analyze the reproducibility of cardiac M...

Background Cardiac magnetic resonance imaging (CMR) enables infarct and edema size measurement on LGEand T2wCMR, respectively. However, evaluation of infarct and edema size using a threshold method is time consuming and relies on accurate placement of normal regions of interest and manual delineation of the respective areas. The purpose of the study was to analyze the accuracy and expenditure o...