نتایج جستجو برای: inducing ligand

تعداد نتایج: 169340  

Journal: :The Journal of clinical investigation 1997
S A Buechner M Wernli T Harr S Hahn P Itin P Erb

Basal cell carcinoma (BCC) is the most common skin cancer in humans, and although metastasis rarely occurs, the tumor cells are nevertheless able to invade and destroy the surrounding tissue. Intralesional injection of IFN-alpha has been found to be highly effective in inducing BCC regression by an unknown mechanism. We show that in untreated patients, BCC cells express CD95 ligand, but not the...

Journal: :Journal of the American Chemical Society 2009
Patrick H N Celie Mireille Toebes Boris Rodenko Huib Ovaa Anastassis Perrakis Ton N M Schumacher

High-throughput structure determination of protein-ligand complexes is central in drug development and structural proteomics. To facilitate such high-throughput structure determination we designed an induced replacement strategy. Crystals of a protein complex bound to a photosensitive ligand are exposed to UV light, inducing the departure of the bound ligand, allowing a new ligand to soak in. W...

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