Introduction: The brain glutamate system plays a central role in response to stress. This study examines the effect of memantine (a NMDA glutamate receptor antagonist) on stress from plantar electrical shock in male NMRI mice (Pasture Institute, Iran), weighing 25-30 g (n=6/group). Methods: The nucleus accumbens was bilaterally cannulated in a group of animals, and seven days later, differen...

Objective(s): The present study aims to evaluate the protective effect of the compounds isolated from Echinophora cinerea (E. cinerea) against oxidative stress and apoptosis induced by cisplatin (CIS) in PC12 cells. Materials and Methods: Six compounds were isolated as quercetrin-3-O-β-D-glucopyranoside (QUE), osthol (OST), verbenone-5-O-β-D-glycopyranoside (VER), Isoimperatorin (ISO), kaempfer...

objective(s):paclitaxel is a potent chemotherapy agent with severe side effects, including allergic reactions, cardiovascular problems, complete hair loss, joint and muscle pain, which may limit its use and lower its efficiency. the cardioprotective effect of royal jelly was investigated on paclitaxel-induced damages. materials and methods:adult male wistar rats were divided into control and te...

background: the role of oxidative stress in endosulfan-induced reproductive toxicity has been implicated. this study was performed to evaluate the possible protective effect of vitamins e and c, against endosulfan-induced reproductive toxicity in rats. methods: fifty adult male sprague–dawley rats were randomly divided into five groups (n=10 each). the groups included a control receiving vehicl...

the effects of some histaminergic agents were evaluated on stress- induced immunosuppression in immunized nale rats. in rat immunized with sheep red blood cells ( srbcs). restraint stress (rs) prevented the booster-induced rise in anti-srbc antibody titre and cell immunity response. intracerebroventicular (i.c>v) injection of histamine (150 µg/rat) induced a similar effect with rs. pretreatment...

this study was conducted to evaluate the cytoprotection of various extracts and bioactive compounds found in pistacia vera againts cytotoxicity, ros formation, lipid peroxidation, protein carbonylation , mitochondrial and lysosomal membrane damages in cell toxicity models of diabetes related carbonyl (glyoxal) and oxidative stress (hydroperoxide). methanol, water and ethyl acetate were used to ...

conclusions it may be concluded that combination of losartan with higher dose of va decreases ischemic markers and lipid peroxidation and augments endogenous antioxidant and hence, protects myocardium against i/r-induced oxidative stress injuries. results there was a more significant decrease in the levels of ldh, cpk, ck-mb, and mda as well as increase in the levels of sod, cat and gpx in grou...

Background: Stress may cause damages to DNA or/and change the ability of the cells to overcome these damages. It may also cause irregularities in the cell cycle and induce abnormal cell divisions through glucocorticoid-dependent functions. The abnormal cell divisions, in turn, lead to chromosomal mal-segregation and aneuploidy. In this study, the effects of the stress hormone, hydrocortisone (H...