نتایج جستجو برای: induced pluripotent stem cells ipsc
تعداد نتایج: 2213628 فیلتر نتایج به سال:
Generation of induced pluripotent stem cells (iPSC) is considered one of the major biological discoveries of the 21st century. IPSC were originally obtained in 2006-2007 by Japanese scientists first from mouse fibroblasts, and later from adult human fibroblasts [1,2]. IPSC have provided a unique platform for studying pathogenesis of different diseases and opened the door to their clinical appli...
Vascular smooth muscle cells (SMC) play an essential role in remodeling the vasculature during disease progression. Induced pluripotent stem cells (iPSC) provide an attractive approach to obtain autologous SMC source for patient-specific disease modeling. Here we discuss the current methods to 1) derive functional SMC from iPSC, 2) model vascular diseases using SMC generated from patient-derive...
BACKGROUND Aging and aging-related disorders impair the survival and differentiation potential of bone marrow mesenchymal stem cells (MSCs) and limit their therapeutic efficacy. Induced pluripotent stem cells (iPSCs) may provide an alternative source of functional MSCs for tissue repair. This study aimed to generate and characterize human iPSC-derived MSCs and to investigate their biological fu...
A b s t r a c This experiment was designed to investigate the roles of induced pluripotent stem cells and hormonal therapy on experimentally-induced ovarian ablation (OA) by evaluating hormonal, molecular, histopathological immunohistochemical examinations. Fifty female rats classified into five main groups. Group (I):10 as control normal group. II (OA): 10 injecteded with (3 mg/kg) DOX (50 mg)...
in July 2009, two research groups indep endently reported the first successful generation of adult mice from induced pluripotent stem cells (ipScs; Kang et al, 2009; zhao et al, 2009). these experiments are part of ongoing research into the dif ferences and similarities between ipScs— which are derived from normal somatic cells by the activation of certain key genes—and embryonic stem cells (...
Aging is accompanied by the functional decline of cells, tissues, and organs, as well as a striking increase in a wide range of diseases. The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) opens new avenues for the aging field and has important applications for therapeutic treatments of age-related diseases. Here we review emerging studies on how aging and age-related ...
Recently developed reprogramming and genome editing technologies make possible the derivation of corrected patient-specific pluripotent stem cell sources-potentially useful for the development of new therapeutic approaches. Starting with skin fibroblasts from patients diagnosed with cystic fibrosis, we derived and characterized induced pluripotent stem cell (iPSC) lines. We then utilized zinc-f...
Generation of induced pluripotent stem cells (iPSCs) generally uses fibroblastic cells, but other cell sources may prove useful in both research and clinical settings. Although proof of cellular origin requires genetic-marker identification in both target cells and established iPSCs, somatic cells other than mature lymphocytes mostly lack such markers. Here we show definitive proof of direct re...
The current study designed to evaluate the role of pluripotent stem cells (iPSc) on experimentally-induced ovarian ablation (OA) by evaluating hematological parameters, FSH and E2 changes, molecular histopathological examination. 50 female rats were divided into five groups with 10 in each group. Group (1): control (2): injected Doxorubicin (DOX) (3 mg/kg) Cyclophosphamide (CYP) (50mg/kg) disso...
Induced pluripotent stem cells (iPSCs) hold promise for treating skin diseases such as epidermolysis bullosa (EB). An iPSC-based gene therapy EB involves reprogramming, correction, iPSC differentiation, and transplantation of genetically corrected iPSC-derived onto patients. One critical challenge this is inconsistent differentiation iPSCs into high-quality keratinocytes (iKCs) fibroblasts (iFB...
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