in the present study, interactive effects of d1 and d2 dopamine receptors antagonists and different periods of lithium pretreatment on morphine dependence in mice have been investigated. this study was designed to investigate whether the hypothesis that lithium and dopaminergic mechanisms via their effects on phosphoinositide pathways and calcium flux could influence morphine withdrawal respons...

glutathione s-transferases (gsts; ec: 2.5.1.18) are a ubiquitous family of eukaryotic and prokaryotic phase ii metabolic isozymes. genes encoding gstm1 (omim: 138350), and gstt1 (omim: 600436) are members of class mu and theta, respectively. the most common polymorphism in the gstm1 is a deletion of the whole gstm1 gene with a lack of enzyme activity. a homozygous deletion in the gstt1 has also...

bubbles in asset prices have fascinated researchers in finance. identify asset bubbles, by circumstances, on the stock market has been a growing number of research theoretical and empirical. on a theoretical level, it was assumed that the price dynamics reflect irrational behavior of economic agents and, therefore, should be excluded from a deal with the truly rational economic agents burmeiste...

background: morphine and lidocaine are known to influence the perception of pain. the present study sought to determine the influence of local administration of morphine on lidocaine-induced analgesia in morphine non-dependent (mnd), morphine dependent (md) and morphine withdrawal (mw) animals. methods: adult male wistar rats were divided into four groups: control, mnd, md and mw rats. lidocain...

BACKGROUND This study examines how nicotine dependence is distributed across socioeconomic gradients in rural Yunnan province, which has the most ethnic minorities in one province in southwest China. METHODS A cross-sectional survey was conducted in four rural areas of Yunnan province among 17,158 consenting individuals aged ≥18 years in 2011. Information on demographic characteristics and sm...

Ms M. a 13 years old class III student presented with one year history of petrol fumes inhalation dependence and six months history of kerosene inhalation dependence. She liked the smell of fumes getting pleasant feeling of well-being and increased confidence. She though fulfilled all the criteria of inherent dependence differed from typical cases described in published reports. Like male prepo...

OBJECTIVE Substance use in pregnancy is associated with placental abruption, but the risk of fetal death independent of abruption remains undetermined. Our objective was to examine the effect of maternal drug dependence on placental abruption and on fetal death in association with abruption and independent of it. METHODS To examine placental abruption and fetal death, we performed a retrospec...

Background: Loperamide is used as an antidiarrheal drug and is available over-the-counter. It cannot pass the blood-brain barrier and it does not have a considerable abuse potential. It can lead to dangerous cardiac arrhythmia.Case Report: Herein, we report a 35-year-old man with a 13-year history of abusing opioids who had undergone detoxification for four times during this period. He underwen...