Na+- and CA2+-sensitive microelectrodes were used to measure intracellular Na+ and Ca2+ activities (alpha iCa) of sheep ventricular muscle and Purkinje strands to study the interrelationship between Na+ and Ca2+ electrochemical gradients (delta muNa and delta muCa) under various conditions. In ventricular muscle, alpha iNa was 6.4 +/- 1.2 mM and alpha iCa was 87 +/- 20 nM ([Ca/+] = 272 nM). A g...

BACKGROUND Engulfment of apoptotic cells is important for cellular homeostasis and the development of multicellular organisms. Previous studies have shown that more than one engulfment receptors act upstream of the conserved signaling module CED-2/CrkII-CED-5/Dock180-CED-12/ELMO for cell corpse removal in C. elegans, but little is known about their identities, except for PSR-1. RESULTS We sho...

BACKGROUND Cardiovascular resuscitation upon intoxication with lipophilic ion channel-blocking agents has proven most difficult. Recently, favorable results have been reported when lipid rescue therapy is performed, i.e., the infusion of a triglyceride-rich lipid emulsion during resuscitation. However, the mechanism of action is poorly understood. METHODS The authors investigate the effects o...

BACKGROUND The mechanisms of the electrocardiographic changes and arrhythmias in Brugada syndrome (BrS) remain controversial. Mutations in the sodium channel gene, SCN5A, and regulatory proteins that reduce or eliminate sodium current (INa) have been linked to BrS. We studied the properties of a BrS-associated SCN5A mutation in a protein kinase A (PKA) consensus phosphorylation site, R526H. M...

BACKGROUND First Nation residents within Personal Care Homes (PCHs) are the most vulnerable segment of First Nations society and are in need of continuing care. Recent conditions imposed through unilateral decision-making by the federal government are placing the existence and continued operations of PCHs in jeopardy. METHODS This article documents the current state of First Nation PCHs in Ma...

Frank Ortmann1,2 and Stephan Roche2,3 1Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Institut Nanosciences et Cryogénie (INAC), Structure et Propriétés d’Architectures Moleculaires (SPRAM), Groupe Théorie, 17 rue des Martyrs, F-38054 Grenoble Cedex 9, France 2CIN2 (ICN-CSIC) and Universitat Autónoma de Barcelona, Catalan Institute of Nanotechnology, Campus de la UAB, E-0...

Yu Li,1 Weiyi Wang,1 Yu Song,1 Haoran Man,1 Xingye Lu,2 Frédéric Bourdarot,3 and Pengcheng Dai1,2,* 1Department of Physics and Astronomy, Rice University, Houston, Texas 77005, USA 2Center for Advanced Quantum Studies and Department of Physics, Beijing Normal University, Beijing 100875, China 3Univ. Grenoble Alpes. CEA, DRF, INAC, MEM/MDN, F-38000 Grenoble, France (Received 16 May 2017; publish...

We built an integrated nonlinear analysis software (INA)-designed to study space plasma turbulence and intermittency. The MATLAB programming environment was used for the algorithmic development implementation of methods spectral analysis, multiscale fluctuations multifractal analysis. performance INA is demonstrated using magnetic field measurements during inbound pass through Earth's magnetosh...

Julia S. Meyer1 and Gil Refael2,3 1SPSMS, UMR-E 9001 CEA/UJF-Grenoble 1, INAC, Grenoble, F-38054, France 2Department of Physics, California Institute of Technology, MC 149-33, 1200 E. California Blvd., Pasadena, California 91125, USA 3Dahlem Center for Complex Quantum Systems and Fachbereich Physik, Freie Universität Berlin, 14195 Berlin, Germany (Received 22 November 2012; published 26 March 2...

Dynamic nuclear polarization (DNP) has the potential to enhance the sensitivity of magic-angle spinning (MAS) NMR by many orders of magnitude and therefore to revolutionize atomic resolution structural analysis. Currently, the most widely used approach to DNP for studies of chemical, material, and biological systems involves the cross-effect (CE) mechanism, which relies on biradicals as polariz...