gamma-scintigraphy is applied extensively in the development and evaluation of pharmaceutical delivery systems, particularly for monitoring formulations in the gastrointestinal and respiratory tracts. the radiolabelling is generally achieved by the incorporation of an appropriate radionuclide such as technetium-99m or indium-111 into the formulation or by addition of a non-radioactive isotope s...

backgrounds: bleomycin (blm) has been labeled with radioisotopes and widely used in therapy and diagnosis. in this study blm was labeled with [62zn] zinc chloride for oncologic pet studies. materials and methods: the complex was obtained at the ph=2 in normal saline at 90 ° c in 60 min. radio-tlc showed an overall radiochemical yield of 95-97% (radiochemical purity > 97%). stability of complex ...

hydrogel based metronidazole bioadhesive tablet (hmbt) was prepared as a novel vaginal delivery system to achieve controlled release of drug from the tablet for vaginal candidiasis. the highly swollen hydrogel were prepared by dissolving chitosan in acetic acid solution containing drug, followed by neutralisation with sodium hydroxide and characterized by sem, dsc and ft-ir and evaluated for % ...

introduction: delivering maximum dose to tumor and minimum dose to normal tissues is the most important goal in radiotherapy. according to icru, the maximum acceptable uncertainty in the delivered dose compared to the prescribed dose should be lower than 5%, and this is because of the relationship between absorbed dose, tumor control and normal tissue damage. absorbed dose accuracy is investiga...

objective: the role of herbs against the free radicals have been put forth recently in combating many diseases. the aim of this study was to elucidate the in vitro capacity and in vivo antioxidant properties of sedimental extract of tinospora cordifolia (setc). materials and methods: setcwas subjected to in vitro chemical analysis such as 1,1-diphenyl-2-picrylhydrazyl (dpph), nitric oxide, hydr...

OBJECTIVES To optimize the Trypanosoma brucei brucei GVR35 VSL-2 bioluminescent strain as an innovative drug evaluation model for late-stage human African trypanosomiasis. METHODS An IVIS® Lumina II imaging system was used to detect bioluminescent T. b. brucei GVR35 parasites in mice to evaluate parasite localization and disease progression. Drug treatment was assessed using qualitative biolu...