Among the various anions, only cyanide induced the revival of fluoresecence of -Cu(2+) resulting in "Off-On" type sensing of cyanide, which can be monitored at pH 7.4 in 100% aqueous system, and has been applied to a microfluidic platform, in which fluorescent sensor -Cu(2+) displayed green fluorescence upon the addition of cyanide, the in vivo imaging of cyanide using Caenorhabditis elegans.

Herein, we describe a fast and robust method for achieving (68)Ga-labelling of the EGFR-selective monoclonal antibody (mAb) Cetuximab using the bioorthogonal Inverse-electron-Demand Diels-Alder (IeDDA) reaction. The in vivo imaging of EGFR is demonstrated, as well as the translation of the method within a two-step pretargeting strategy.

Silicon diode dosimeters have been used routinely for in-vivo dosimetry. Despite their popularity, an appropriate implementation of an in-vivo dosimetry program using diode detectors remains a challenge for clinical physicists. One common approach is to relate the diode readout to the entrance dose, that is, dose to the reference depth of maximum dose such as d(max) for the 10x10 cm(2) field. V...

BACKGROUND Total skin electron irradiation (TSEI) is a special radiotherapy technique which has generally been used for treating adult patients with mycosis fungoides. Recently, two infants presented with leukemia cutis isolated to the skin requiring TSEI. This work discusses the commissioning and quality assurance (QA) methods for implementing a modified Stanford technique using a rotating har...

PURPOSE To report the results of a correlation analysis of skin dose assessed by in vivo dosimetry and the incidence of acute toxicity. This is a phase 2 trial evaluating the feasibility of intraoperative radiotherapy (IORT) as a boost for breast cancer patients. MATERIALS AND METHODS Eligible patients were treated with IORT of 20 Gy followed by whole breast irradiation (WBI) of 46 Gy. A tota...

Entrance and exit doses are commonly measured in in vivo dosimetry for comparison with expected values, usually generated by the treatment planning system (TPS), to verify accuracy of treatment delivery. This report aims to evaluate the accuracy of six TPS algorithms in computing entrance and exit doses for a 6 MV beam. The algorithms tested were: pencil beam convolution (Eclipse PBC), analytic...

This study analyses the thermally stimulated luminescence (TSL) or thermoluminescence glow curve between 300 and 773 K of germanium-doped silica optical fibre and finds a main glow peak at around 500 K with a characteristic spectral emission centred at 400 nm. Both features are particularly suitable for dosimetry. Thus, an investigation by the TSL technique of some first clinically relevant fea...

Semiconductor radiation detectors play an important role in radiation instrumentation. They have many advantages due to their small size, outstanding energy resolution in nuclear spectroscopy, easy pixilation for high spatial resolution and ability of integration with readout electronics. Advancement in microelectronic industry made silicon one of the most popular material for radiation detecto...

background: in order to obtain an anti-cd20 conjugate to be used in future therapeutic studies with therapeutic radioisotopes, 67ga-labeled antibody was prepared as a model of metal chelated immunoconjugate for preliminary dosimetric and biodistribution studies. materials and methods: rituximab was labeled with [67ga]-gallium chloride after residulation with freshly prepared cyclic dtpadianhydr...