In situ gelling systems are becoming one of the most popular and well-known, with many potential benefits from delivery systems, such as ease use manufacture, improve adherence patient comfort by minimizing frequency drug administration. this review, we will describe characterization evaluation ophthalmic in gel preparation. Among them physical (appearance clarity, pH, isotonicity, gelation tem...

The authors evaluated and compared the efficacies of eye drops and in situ forming gel of pefloxacin mesylate in pseudomonas induced conjunctivitis in 40 rabbits. The in-situ forming gel of pefloxacin mesylate was formulated as a liquid and when administered in the cul-de-sac, it gets converted to gel. The objective of the present research work was to demonstrate the in vivo activity of in situ...

styrene nanocomposites were synthesized by in-situ atom transfer radical polymerization at 110oc. the variations of monomer conversion and the linearity of semilogarithmic kinetic plot, some signs of living polymerizationand constant radical concentration in the reaction medium, were revealed by gas chromatography technique (gc). according to the gel permeation chromatography (gpc) results, the...

BACKGROUND AND THE PURPOSE OF THE STUDY The poor bioavailability and therapeutic response exhibited by the conventional ophthalmic solutions due to precorneal elimination of the drug may be overcome by the use of mucoadhesive in situ gel forming systems that are instilled as drops into the eye and undergo a sol-gel transition in the cul-de-sac and have good mucoadhesion with ocular mucus layers...