Double emulsions are normally considered as metastable systems and this limit in stability restricts their applications. To enhance their stability, the outer shell can be converted into a mechanically strong layer, for example, a polymeric layer, thus allowing improved performance. This conversion can be problematic for food and drug applications, as a toxic solvent is needed to dissolve the p...

Acne vulgaris is a chronic and prevalent usually self-limited disorder. Topical medication is the main route for acne therapy. In this disorder the most widely used topical preparations are antibiotics such as Erythromycin and keratolytic agents such as Tretinoin. Excellent results with minimal side effects may be achieved by a fixed combination of Tretinoin and Erythromycin. This combination t...

In this paper, carbon nanotubes (CNTs) were added into chitosan (CS) hydrogels in the form of chitosan modified CNTs (CS-CNTs) composites to prepare carbon nanotubes hydrogels (CNTs-GEL). The products, named CS-MWCNTs, were characterized by scanning electron microscope (SEM) and Fourier transform infrared (FTIR) spectroscopy. Swelling properties and effect of pH on controlled release performanc...

      Benzoyl peroxide (BPO) is a first-line topical treatment in acne vulgaris, and it is superior to antibiotics, because the bacteria do not develop resistance to it. Skin irritation is a common side effect, and it has been shown that controlled release of BPO from a delivery system to the skin could reduce the side effects while reducing percutaneous absorption. Therefore, the purpose of t...

The Parenteral administration route is the most effective and common form of delivery for active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. Though parenteral administration of drug is often critical and associated with problems such as limited number of acceptable excipients, stringent requirements of aseptic production process, safety issues, pati...

The present investigation was aimed to formulate and characterize ion-activated in-situ gel loaded with Rizatriptan Benzoate (RIZ) for intranasal administration brain targeting. further optimized process formulation parameters by using 32 factorial design. batch having the concentrations of gellan gum HPMC E15 LV 33.83 mg 9.6 respectively. Gel strength mucoadhesive were found be 32.54 sec 2580....

a hydrophilic macromolecular network is prepared by performing graft copolymerization of poly (sodium acrylate) chains onto salep and silica gel. the reaction parameters affecting the water absorbency of the superabsorbent composite were optimized using taguchi method. ft-ir spectroscopy and thermo gravimetric analysis (tga) were used for confirming the structure of the final product and morpho...

Background: The excellent biocompatibility, biodegradability and biological properties of the hydrogels, fabricated using natural polymers, especially polysaccharides, are very advantageous for biomedical applications. Gum tragacanth (GT) is a heterogeneous highly branched anionic polysaccharide, which has been used extensively in food and pharmaceutical industries. Despite,  its desirable prop...

Hydrogels In article number 2008793, Won Jong Kim and co-workers introduce an injectable in situ polymeric aggregate-embodied hybrid hydrogel (M-NO gel) to achieve nitric oxide (NO)-scavenging sequential drug-release for the combinatorial treatment of rheumatoid arthritis. This novel M-NO gel platform incorporated with a “clickable” NO-cleavable crosslinker is expected prove guideline various N...