Bioequivalence testing aims to ensure that the therapeutic performance of drug is consistent and reproducible when it administrated. Modeling simulation in silico methods are currently performed conduct virtual bioequivalence studies. Various computer software used generate model input data. This review summarizes for predicting vivo which supports analysis testing. GastroPlus™ SimCyp® widely p...

conclusions the growth rate of information in bioinformatics databases could facilitate studies of live organisms prior to observation studies. two different protein classes could be causative agents of one disease. however, two related diseases from one disease group could consist of different protein classes. future research in the field of proteomics could allow modern insight to reshuffling...

neisseria meningitidis is a major causative agent of bacterial septicemia and meningitis in humans. currently, there are no vaccines to prevent disease caused by strains of n.meningitidis serogroup b. the class 1 outer membrane protein (omp) has been named pora which is a cation selective transmembrane protein of 45 kda that forms trimeric pore in the meningococcal outer membrane. pora from ser...

The haemolytic biovar of Gallibacterium anatis (G. anatis) is responsible for urogenital, gastrointestinal, and respiratory diseases in chickens. There are numerous reports on the resistance of G. anatis to antibiotics and recurrence of the disease, which raise concerns about antimicrobial treatment efficiency. Vaccination has been considered as the most feasibl...

Coagulation factors belong to a family of plasma glycosylated proteins that should be activated for appropriate blood coagulation. Congenital deficiencies of these factors cause inheritable hemorrhagic diseases. Factor VII (FVII) deficiency is a rare bleeding disorder with variable clinical symptoms. Various mutations have been identified throughout the F7 gene and can affect all the protein do...