We describe here a pathway for the import of proteins into the intermembrane space (IMS) of mitochondria. Substrates of this pathway are proteins with conserved cysteine motifs, which are critical for import. After passage through the TOM channel, these proteins are covalently trapped by Mia40 via disulfide bridges. Mia40 contains cysteine residues, which are oxidized by the sulfhydryl oxidase ...

Within the past decade, imaging mass spectrometry (IMS) has been increasingly recognized as an indispensable technique for studying biological systems. Its rapid evolution has resulted in an impressive array of instrument variations and sample applications, yet the tools and data are largely confined to specialists. It is therefore important that at this junction the IMS community begin to esta...

Isochronous Mass Spectrometry (IMS) in the ESR has successfully applied recently [1]. At FAIR, IMS will be performed in the Collector Ring (CR) in combination with the Super-FRS and thus substantially extend the reach of mass measurements to more exotic ions. In IMS the masses of the nuclei are directly determined from the revolution frequencies measured by a microchannel plate (MCP) time-of-fl...

The integration of IMS networks will enable telecom operators to evolve in a manner transparent to the incessant demand for the multimedia services. However the QoS management mechanisms defined for IMS networks are considered poor in oversight and monitoring real-time services. Moreover the eTOM Framework includes the scenarios of monitoring service delivery that enable real-time tracking serv...

The index matrix (IM) is an extension of the ordinary with indexed rows and columns. Over IMs’ standard operations are defined a lot other ones that do not exist in case. Intuitionistic fuzzy IMs (IFIMs) modification IMs, when their elements intuitionistic pairs (IFPs). Extended IFIMs whose indices columns evaluated by IFPs. Different operations, relations operators over IFIMs, some specific on...

According to the narrative approach, change in self-narratives is an important part of successful psychotherapy. In this view, several authors have highlighted the usefulness of narrating new experiences (like actions, thoughts, and stories) during therapy in contrast with maladaptive client self-narratives. These new experiences are termed here innovative moments (IMs), and different types can...

Ion mobility spectrometry (IMS) has potential analytical applications in very diverse fields such as chemical, petrochemical, environmental, and, more recently, in drug, chemical warfare agent, and explosives detection. Commercially available IMS instruments are based on time-of-flight (TOF) mass spectrometry. IMS is inherently suitable for field operation as it uses relatively simple microflui...

Mitochondrial protein import is thought to involve the sequential interaction of preproteins with binding sites on cis and trans sides of the membranes. For translocation across the outer membrane, preproteins first interact with the cytosolic domains of import receptors (cis) and then are translocated through a general import pore, in a process proposed to involve binding to a trans site on th...

Porcine intestinal spirochaetes are fastidious anaerobic organisms and, as a consequence, it has been necessary to develop various protocols to enhance their isolation from or detection in faeces. Immunomagnetic separation (IMS) is a method developed recently to improve separation of target cells from mixed cell suspensions. The purpose of the present study was to compare the relative sensitivi...

Defense against infection by Mycobacterium tuberculosis (Mtb) is mediated by CD4 T cells. CCR2(+) inflammatory monocytes (IMs) have been implicated in Mtb-specific CD4 T cell responses but their in vivo contribution remains unresolved. Herein, we show that transient ablation of IMs during infection prevents Mtb delivery to pulmonary lymph nodes, reducing CD4 T cell responses. Transfer of MHC cl...