Background: Undifferentiated spondyloarthritis (USpA) is the most common subtype of spondyloarthritides with a prevalence between 0.7% and 2.0% 1 . Inflammatory back pain, peripheral arthritis less frequently enthesitis are main clinical features USpA 2 Resently role dysregulated microbiome along migration T lymphocytes other cells from gut to joint (“gut-joint” axis) has been recognized 3 4 Ho...

Anticancer immunotherapies are highly desired. Conversely, unwanted inflammatory or immune responses contribute to oncogenesis, tumor progression, and cancer-related death. For non-immunogenic therapies to inhibit tumor growth, they must promote, not prevent, the activation of anticancer immune responses. Here, the central immunoregulatory role of brain-specific stromal cells and neurons as wel...

The period from 3 wk before to 3 wk after parturition in dairy cows, also known as the transition period, is characterized by significant changes in hormonal profile, feed intake, nutrient requirements, metabolism, and energy balance. These changes are known to dramatically affect immune function. In this manuscript we will discuss situations that accentuate immune suppression and predispose co...

Tryptophan (Trp) catabolism into immunosuppressive kynurenine (Kyn) by indoleamine 2,3-dioxygenase (IDO) was previously linked to Th17/Treg differentiation and immune activation. Here we examined Trp catabolism and its impact on Th17/Treg balance in uninfected healthy subjects (HS) and a large cohort of HIV-infected patients with different clinical outcomes: ART-naïve, Successfully Treated (ST)...

Human immunodeficiency virus (HIV) immunopathogenesis in children remains poorly understood. We assessed T cell immune activation in antiretroviral therapy-naive children in Uganda (n=154). Increased CD4+ and CD8+ T cell activation strongly correlated with decreased CD4+ T cell percentage. Interestingly, no correlation between plasma HIV RNA level and T cell activation was observed after contro...

Modulation of the maternal-foetal immune response, designed to benefit the gestation of an individual whose genetic material is foreign to that of the mother, since 50% is of paternal origin, is a unique, highly complex biological process involving the father, mother and child. The first signals emitted by the seminal fluid already promote the beginning of immune adaptation, in which the antige...

Non-classical MHC class Ib molecules have attracted growing interest in recent years, especially because they interact with non-T-cell inhibitory or triggering receptors expressed on natural killer (NK) and T cells, suggesting that they have a role in immune recognition. Abnormalities in MHC class Ib expression are frequently found in human tumors of various histologies and might be associated ...

1. Organisms must contend with seasonal fluctuations in energy availability. To maintain a positive energy balance year-round, a number of adaptations have evolved including seasonal changes in reproduction, energetics and immunity. Photoperiod is the primary environmental signal most animals use to predict seasonal events. Despite the established link between energetics and immune function, li...

Fc gamma receptors (Fc gammaRs) bind the constant Fc region of IgG molecules. IgG/antigen-containing immune complexes elicit a variety of effector functions in cells that express activating Fc gammaRs. Because activating Fc gammaRs are present on cells from the innate immune system, such as dendritic cells, monocytes/macrophages and granulocytes, these IgG receptors form a crucial link between ...