The title anilide-imine compound, C(24)H(26)N(2)O, features an intra-molecular N-H⋯N hydrogen bond involving the imine and anilide groups to generate an S(6) ring motif. The mol-ecule displays an E configuration about the imine C=N double bond, with the dihedral angle between the two benzene rings being 86.5°. The packing is stabilized by three different C-H⋯π inter-actions.

Idiosyncratic hepatotoxicity has been associated with the oral tyrosine kinase inhibitor lapatinib, which is used in metastatic breast cancer therapy. Lapatinib is extensively metabolized by cytochrome P450 3A4/5 to yield an O-debenzylated metabolite, which can undergo further oxidation to a reactive quinone imine. A recent clinical study reported that concomitant use of lapatinib with dexameth...

The ternary iron(II) complex [Fe(L')(L")](PF6)3(1) as a synthetic model for the bleomycins, where L' and L" are formed from metal-mediated cyclizations of N,N'-(2-hydroxypropane-1,3-diyl)bis(pyridine-2-aldimine)(L), is synthesized and structurally characterized by X-ray crystallography. In the six-coordinate iron(ii) complex, ligands L' and L" show tetradentate and bidentate chelating modes of ...

The metalation reactions between [Pt2(4-MeC6H4)4(μ-SEt2)2] and 2-X,6-FC6H3CH[double bond, length as m-dash]NCH2CH2NMe2 (X = Br, Cl) have been studied. In all cases, seven-membered platinacycles are formed in a process that involves an initial reductive elimination from cyclometallated Pt(IV) intermediate compounds, [PtX(4-CH3C6H4)2(ArCH[double bond, length as m-dash]NCH2CH2NMe2)] (X = Br, Cl), ...

Novel hybrid material poly(imide-imine) has been prepared, which exhibits self-healing behavior and recyclability enabled by the dynamic imine bonds while retaining tunable excellent mechanical thermal properties of polyimide.

Free imine imidazol-2-imine ligands with two different substitution patterns have been isolated for the first time and they were found to exist as an equilibrium mixture of geometric and mesomeric isomers. The relative ratios of these isomers are dependent on both the nature of the substituents and of the solvent. The synthesis of the titanium(IV) alkyl and arylimido complexes of these ligands ...

This paper presents the IMine index, a general and compact structure which provides tight integration of item set extraction in a relational DBMS. Since no constraint is enforced during the index creation phase, IMine provides a complete representation of the original database. To reduce the I/O cost, data accessed together during the same extraction phase are clustered on the same disk block. ...

Ab initio and DFT calculations reveal that both imidoyl and thioyl radicals add to the nitrogen end of methanimine through simultaneous SOMO-π*(imine), SOMO-π(imine), SOMO-LP(N) and π*(radical)-LP(N) interactions between the radical and the imine. At the CCSD(T)/cc-pVDZ//BHandHLYP/cc-pVTZ level of theory, barriers of 13.8 and 26.1 kJ mol(-1) are calculated for the attack of the methylimidoyl ra...

An experimental and theoretical study of the reactivity mechanism non-catalyzed catalyzed Povarov reaction for preparation a 4-ethoxy-2,3,4,4a-tetrahydro-2-phenylquinoline as biological active quinoline derivative has been performed. The optimization conditions indicate that use catalyst, namely Lewis acid with an electron-releasing group, creates best this kind reaction. chemical structure was...