Intron length polymorphisms (ILPs) have been used as genetic markers in some studies. However, a systematic investigation and large-scale exploitation of ILP markers has not been reported. In this study, we performed a genome-wide search of ILPs between two subspecies (indica and japonica) in rice using the draft genomic sequences of cultivars 93-11 (indica) and Nipponbare (japonica) and 32,127...

A key problem in QSAR is the selection of appropriate descriptors to form accurate regression equations for the compounds under study. Inductive Logic Programming (ILP) algorithms are a class of machine learning algorithm that have been successfully applied to a number of SAR problems. Unlike other QSAR methods, which use attributes to describe chemical structure, ILP uses relations. This gives...

We present stable ILP, a cross-disciplinary concept straddling machine learning and nonmonotonic reasoning. Stable models give meaning to logic programs containing negative assertions. In stable ILP, we employ stable models to represent the current state speciied by (possibly) negative EDB and IDB rules. The state then serves as the background knowledge for a top-down ILP learner. We present a ...

We present stable ILP, a cross-disciplinary concept straddling machine learning and nonmonotonic reasoning. Stable models give meaning to logic programs containing negative assertions. In stable ILP, we employ stable models to represent the current state speciied by (possibly) negative EDB and IDB rules. The state then serves as the background knowledge for a top-down ILP learner. We present a ...

The weighted constraint satisfaction problem (WCSP) occurs in the crux of many real-world applications of operations research, artificial intelligence, bioinformatics, etc. Despite its importance as a combinatorial substrate, many attempts for building an efficient WCSP solver have been largely unsatisfactory. In this paper, we introduce a new method for encoding a (Boolean) WCSP instance as an...

In chemoinformatics, searching for compounds which are structurally diverse and share a biological activity is called scaffold hopping. Scaffold hopping is important since it can be used to obtain alternative structures when the compound under development has unexpected side-effects. Pharmaceutical companies use scaffold hopping when they wish to circumvent prior patents for targets of interest...