Influenza H7N9 virus infection causes an acute, highly contagious respiratory illness that triggers cell death of infected cells and airway epithelial destruction. RIP3 is a key regulator of cell death responses to a growing number of viral and microbial agents. This study aimed to investigate the role of RIP3 in inflammation of influenza H7N9 virus infection. Here, RIP3 knock out (RIP3-/-) mic...

The first day of the conference was devoted to basic science. Fabio Martinon (Switzerland) got the first session underway with a presentation on innate immunity. The innate immune system detects pathogens and other danger signals, activating tolllike receptors (TLRs) in the cell membrane and NOD-like receptors within the cell. These receptors regulate inflammatory responses and apoptosis (progr...

Background: The autoimmune regulator gene ( AIRE ) has very important role in self-tolerance. Estrogen induced hypermethylation of promoter was put forward as one the reasons for susceptibility to autoimmunity females. [1] Sulphasalazine is a commonly used drug rheumatology and known be responsible various side effects. Objectives: We aimed investigate effects treatments on methylation status l...

Introduction: Gliomas are the most prevalent type of primary intracranial tumors, representing 80% all brain neoplasms.In Sudan Brain tumors have been as leading cause mortality among children and thirdcausative death young adults.World Health Organization (WHO) classification2021, categorized gliomas into lower-grades (LGG,grades II III) andglioblastoma (GBM, grade IV).Gliomas surrounded by po...