نتایج جستجو برای: il 15
تعداد نتایج: 627023 فیلتر نتایج به سال:
Natural killer (NK) cells are innate immune effectors that mediate rapid responses to viral antigens. Interleukin (IL)-15 and its high affinity IL-15 receptor, IL-15Ralpha, support NK cell homeostasis in resting animals via a novel trans presentation mechanism. To better understand how IL-15 and IL-15Ralpha support NK cell activation during immune responses, we have used sensitive assays for de...
Owing to shared receptor components, the biologic activities of IL-15 are similar to those of IL-2. However, the patterns of tissue expression of IL-2/IL-2R alpha and IL-15/IL-15R alpha differ. The development of agents targeting the receptor and signaling elements of IL-15 may provide a new perspective for treatment of diseases associated with expression of IL-15/IL-15R. We designed, genetical...
IL-15 plays many important roles within the immune system. IL-15 signals in lymphocytes via trans presentation, where accessory cells such as macrophages and dendritic cells present IL-15 bound to IL-15Rα in trans to NK cells and CD8(+) memory T cells expressing IL-15/IL-2Rβ and common γ chain (γ(c)). Previously, we showed that the prophylactic delivery of IL-15 to Rag2(-/-)γ(c)(-/-) mice (matu...
هدف پژوهش حاضر تعیین تأثیر فعالیت ورزشی تناوبی شدید در شرایط هایپوکسی و نورموکسی بر پاسخ اینترلوکین-6 (il-6) سرم و ارتباط آن با گلوکز در مردان غیر ورزشکاربود. روش کار: 9 مرد غیرورزشکار داوطلب، با میانگین سنی 5/0±6/24 سال، وزن 9/4±9/72 کیلوگرم و قد 3/5±8/174 سانتی متر در این پژوهش شرکت کردند. آزمودنیها برنامه فعالیت اصلی را به مدت 30 دقیقه شامل 10 تکرار 1 دقیقه ای با بار کار 80 درصد wmax روی چرخ...
Keratinocytes (KC) are important source of and targets for several cytokines. Although KC express IL-15 mRNA, the functional effects of IL-15 on these epithelial cells remain to be dissected. Investigating primary human foreskin KC and HaCaT cells, we show here by semiquantitative RT-PCR and flow cytometric analysis that both translate IL-15 and IL-15R mRNA and express IL-15 and IL-15Ralpha pro...
Atopic dermatitis (AD) lesions are characterized by high expression of interleukin-15 (IL-15), a pleiotropic cytokine that controls NK and T-cell activation keratinocyte apoptosis, although the role IL-15 signaling in AD pathobiology remains unclear. Here, we have explored this novel humanized mouse model, which is based on intradermal injection autologous,in vitro pre-stimulated with IL-4/IL-2...
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