Both ornithine decarboxylase (ODC) and its regulatory protein, antizyme inhibitor (AZI), can bind with antizyme (AZ), but the latter has a higher AZ-binding affinity. The results of this study clearly identify the critical amino acid residues governing the difference in AZ-binding affinities between human ODC and AZI. Inhibition experiments using a series of ODC mutants suggested that residues ...

Center for Evolutionary Functional Genomics, The Biodesign Institute, Arizona State University, Tempe, AZ 85287-5301 School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501 Department of Electrical Engineering, Ira A. Fulton School of Engineering, Arizona State University, Tempe AZ 85287-5706 Department of Computer Science and Engineering, Ira A. Fulton School of Engineering, Ar...

Ornithine decarboxylase (ODC) is the most notable example of a protein degraded by the 26 S proteasome without ubiquitination. Instead, ODC is targeted to degradation by direct binding to a polyamine-induced protein termed antizyme (Az). Antizyme inhibitor (AzI) is an ODC-related protein that does not retain enzymatic activity yet binds Az with higher affinity than ODC. We show here that like O...

In 2004, the first author gave the combinatorial interpretations of four mock theta functions of Srinivasa Ramanujan using n-color partitions which were introduced by himself and G.E. Andrews in 1987. In this paper we introduce a new class of partitions and call them “split (n+t)-color partitions”. These new partitions generalize Agarwal–Andrews (n + t)-color partitions. We use these new combin...

"The Senate urges students and facu l ty either to devote class t ime on the four teenth to discussions of the implications of our Vietnam policy, or to dismiss classes fo r discussion and activities within the larger Houston community. "The Rice Senate aks the student a f f a i r s vice-president to work towards forming a joint committee on the Vietnam Moratorium if possible, through the Houst...

Actinic keratoses (AKs) are pre-malignant skin lesions that occur secondary to extended ultraviolet radiation (UVR) exposure. Limited population-based studies available analyze the risk factors, severity and natural course of AK. The aim this study was calculate prevalence AK investigate its factors progression. Participants from Rotterdam Study (RS), an ongoing prospective cohort study, who un...

Associated Infections Sierra Simmons, MD; Shimon Kusne, MD; Holenarasipur R. Vikram, MD, FACP, FIDSA; Qing Wu, ScD; Ann Marie Roy-Hughes, RN; Janis Blair, MD; Internal Medicine, Mayo Clinic Arizona, Phoenix, AZ; Division of Infectious Diseases, Mayo Clinic Hospital, Phoenix, AZ; Research Biostatistics, Mayo Clinic Arizona, Scottsdale, AZ; Practice and Planning Analysis, Mayo Clinic Arizona, Pho...

Cassava (Manihot esculenta Crantz) plant resists water-deficit stress by shedding leaves leading to adaptive water-deficit condition. Transcriptomic, physiological, cellular, molecular, metabolic, and transgenic methods were used to study the mechanism of cassava abscission zone (AZ) cell separation under water-deficit stress. Microscopic observation indicated that AZ cell separation initiated ...

BACKGROUND The prostatic anterior zone (AZ) is not targeted routinely by TRUS guided prostate biopsy (TRUS-Pbx). MRI is an accurate diagnostic tool for AZ tumors, but is often unavailable due to cost or system restrictions. We examined the diagnostic yield of office based AZ TRUS-Pbx. METHODS 127 men at risk for AZ tumors were studied: Patients with elevated PSA and previous extended negative...