The above observations demonstrated induction of immunological tolerance in vitro in primed IgD-, IgG+ B cells. In these studies, addition of trinitrophenylated (TNP) turkey gammaglobulin (TGG) or TNP ovalbumin conjugates suppressed the secondary in vitro response in mice primed with TNP keyhole limpet hemocyanin (TNP-KLH). Suppression was not a reflection of a shift in kinetics of the antibody...

INTRODUCTION Disturbances in peripheral blood memory B cell subpopulations have been observed in various autoimmune diseases, but have not been fully delineated in rheumatoid arthritis (RA). Additionally, the possible role of tumour necrosis factor (TNF) in regulating changes in specific peripheral blood memory B cell subsets in RA is still unclear. METHODS The frequency and distribution of B...

Immunoglobulin D multiple myeloma (IgD MM) accounts for almost 2% of all myeloma cases. It is associated with an increased frequency of undetectable or small monoclonal (M)-protein levels on electrophoresis; osteolytic lesions; extramedullary involvement; amyloidosis; a lambda (lambda) light chain predilection; renal failure; hypercalcemia; and, often, advanced disease at diagnosis. Immunoglobu...

The American Psychiatric Association recently included Internet gaming disorder (IGD) as a potential diagnosis, recommending that further study be conducted to help illuminate it more clearly. This paper is a summary of the review undertaken by the IGD Working Group as part of the 2015 National Academy of Sciences Sackler Colloquium on Digital Media and Developing Minds. By using measures based...

BACKGROUND The present study identified the neural mechanism of risky decision-making in Internet gaming disorder (IGD) under a probability discounting task. METHODS Independent component analysis was used on the functional magnetic resonance imaging data from 19 IGD subjects (22.2 ± 3.08 years) and 21 healthy controls (HC, 22.8 ± 3.5 years). RESULTS For the behavioral results, IGD subjects...

The inverse Gaussian distribution (IGD) is a well known and often used probability distribution for which fully reliable numerical algorithms have not been available. We develop fast, reliable basic probability functions (dinvgauss, pinvgauss, qinvgauss and rinvgauss) for the IGD that work for all possible parameter values and which achieve close to full machine accuracy. The most challenging t...

Studies show a relationship between social appearance anxiety, aggression, and behavioral addictions. However, the smartphone addiction, Internet Gaming Disorder (IGD) has not been investigated. The present study used self-report survey to examine structural relationships IGD. sample comprised 383 Turkish undergraduate students (50.9% male; 49.1% female), all of who played online videogames. de...

Upon infection, B-lymphocytes expressing antibodies specific for the intruding pathogen develop clonal responses triggered by pathogen recognition via the B-cell receptor. The constant region of antibodies produced by such responding clones dictates their functional properties. In teleost fish, the clonal structure of B-cell responses and the respective contribution of the three isotypes IgM, I...

A myeloma IgD immunoglobulin (designated WAH) that was present in high concentration in plasma ( approximately 3.5 g/dl) was purified in >90% yield by a two-step procedure of ammonium sulfate precipitation plus AcA 34 gel filtration. Although the plasma had been stored for 2 years without the addition of a proteolytic inhibitor, no "spontaneous" degradation was apparent and the isolated IgD rem...

Surface immunoglobulin D (IgD)-positive lymphocytes precoated with monoclonal anti-delta antibody were selectively removed from blood mononuclear cell preparations by "panning" and by fluorescence-activated cell sorter. The depletion of sIgD+ cells did not significantly affect plasma cell responses to pokeweed mitogen PWM). PWM-responsive B cells lacking sIgD and mouse erythrocyte receptors pre...