JEM © The Rockefeller University Press $30.00 Vol. 205, No. 4, April 14, 2008 967-979 www.jem.org/cgi/doi/ 967 10.1084/jem.20072051 Rheumatoid arthritis (RA) is a chronic disease aff ecting the peripheral joints in which abnormalities in the synovium precipitate a destructive process that often leads to cartilage and bone erosion. The autoimmune nature of this disease has been defi ned, in part...

PURPOSE To compare the tensile properties of 4-strand modified Kessler flexor tendon repairs using a looped or single-stranded suture. METHODS We evaluated the mechanical properties of 4-strand Kessler zone II core suture repairs using either looped or single-stranded suture in human flexor digitorum profundus and flexor pollicis longus tendons. Forty repairs were performed on tendons from bi...

conclusions endocarditis is an important disease with a high mortality rate if not treated appropriately. therefore, these patients need more attention. in echocardiography, vegetation and complications of ie such as abscess and paravalvular leakage can be detected. results we studied 35 patients, 45% male and 55% female with a mean age of 56.36 ± 12.44 years. fever (80%) and chills (65.7%) wer...

Epilepsy is a common children's neural disease that is largely controlled by anti-epileptic drugs. Nevertheless, children experience repeated attacks that develop into intractable epilepsy (IE). The aim of the present study was to examine the inherited metabolic abnormalities in children with IE to provide early etiological and symptomatic treatment. Urine and blood samples of 56 children with ...

Pseudorabies virus (PRV) early protein 0 (EP0) contains the RING finger domain with homology to the immediate-early (IE) protein ICP0 of herpes simplex virus type 1 (HSV-1). EP0 was detected by indirect immunofluorescence in the nuclei of the cells transfected with EP0 expression plasmid as is the case in cells infected with PRV. In transient expression assays, EP0 transactivated the PRV IE, th...

The reaction of [4-g1utamic acidjdeamlnc-l-carba-oxytocin (lb) with diazoalkanes yielded the corresponding methyl ester Ie and ethyl ester ld. Alternatively, the methyl ester was prepared by means of carbodiimide or thionyl chloride, or by treating the caesium salt of compound Ib with methyl iodide. [2-0~Methyltyrosine, 4-glutamic acid methyl esterjdeamino-f-carba-oxytccin (liz) was also synthe...

' L aboratoire de G éochim ie e l M étallogén ie (C N R S VA 196), U niversité P ierre et M arie Curie, 4 p la ce Jussieu, 75252 P aris C édex 05 (France) ' Faculty o f Science, U niversity o f Tokyo, Bunkyo-ku, T okyo 113 (Japan) ' D 3G M , IF R E M E R , C entre de Brest, B .P. 337, 29273 Brest C édex (France) 4 L aborato ire de Géochimie, U niversité L ibre de Bruxelles, 50 Av. F.D. Roosevel...

At high latitudes, the climate has warmed at twice the rate of the global average with most changes observed in autumn, winter and spring. Increasing winter temperatures and wide temperature fluctuations are leading to more frequent rain-on-snow events and freeze-thaw cycles causing snow compaction and formation of ice layers in the snowpack, thus creating ice encasement (IE). By decreasing the...

In this investigation, the effect of zinc excess andits interaction with ascorbic acid on some growth parameters (root and shoot, fresh and dry weight, leaf blade area and length of root and stem), proline content, soluble sugars and starch plant were studied on canola. Experimental plants were treated with different concentrations of zinc sulfate ie. 0.7 (control), 50, 100, 250, 500 and 700 mM...

BACKGROUND Substantial infective endocarditis (IE)-related morbidity and mortality may occur even after successful treatment. However, no previous study has explored long-term hard end points (ie, stroke, myocardial infarction, heart failure, cardiovascular death) in addition to all-cause mortality in IE survivors. METHODS AND RESULTS A nationwide population-based cohort study was conducted a...