UNLABELLED Ear diseases are illnesses which represent a relevant group of morbidity. Otitis media, for instance, still is a public health problem today. OBJECTIVE To correlate hospital morbidity of ear diseases according to data from the Information Technology Department of the Public Health Care System -SUS (DATASUS), through the Hospital Information System (SIH) with the Human Development I...

The single nucleotide polymorphism rs55705857, located in a non-coding but evolutionarily conserved region at 8q24.21, is strongly associated with IDH-mutant glioma development and was suggested to be a causal variant. However, the molecular mechanism underlying this association has remained unknown. With a case control study in 285 gliomas, 316 healthy controls, 380 systemic cancers, 31 other ...

The current growing body of evidence for diversity-disturbance relationships suggests that the peaked pattern predicted by the intermediate disturbance hypothesis (IDH) may not be the rule. Even if ecologists could quantify the diversity-disturbance relationship consistent with the IDH, the applicability of the IDH to land management has rarely been addressed. We examined two hypotheses related...

Purpose: Isocitrate dehydrogenase (IDH) genemutations occur in low-grade andhigh-grade gliomas.We sought to identify the genetic basis of malignant phenotype heterogeneity in IDH-mutant gliomas. Methods: We prospectively implanted tumor specimens from 20 consecutive IDH1-mutant glioma resections intomouse brains and genotyped all resection specimens using a CLIA-certifiedmolecular panel. Glioma...

Intradialytic hypotension (IDH) is the most common complication of hemodialysis (HD), occurring in up to 20 to 33% of sessions (Daugirdas, 2001). IDH is responsible for various minor symptoms (nausea, vomiting, muscle cramps, dizziness, and fatigue) during dialysis, but is also associated with more severe adverse events such as myocardial infarction (Burton et al., 2009) and cerebral ischemia (...

A significant fall in BP during dialysis, so-called intradialytic hypotension (IDH), is an important clinical problem. IDH is common, occurring in 15%–20% of treatments.1 IDH is often associated with distressing symptoms such as lightheadedness, weakness, muscle cramps, and nausea and vomiting. As could be imagined, reducing blood flow to vital organs, even transiently, is associated with a pan...

Although whole-organism aspects of life-history physiology are well studied and molecular information (e.g., transcript abundance) on life-history variation is accumulating rapidly, much less information is available on the biochemical (enzymological) basis of life-history adaptation. The present study investigated the biochemical and molecular causes of specific activity differences of the lip...

The World Health Organization (WHO) classification of central nervous system (CNS) tumors was revised in 2016 with a basis on the integrated diagnosis of molecular genetics. We herein provide the guidelines for using molecular genetic tests in routine pathological practice for an accurate diagnosis and appropriate management. While astrocytomas and IDH-mutant (secondary) glioblastomas are chara...

Infective dermatitis associated with HTLV-I (IDH) is a chronic, recurrent, exudative eczema occurring in childhood which is considered to be a risk factor for the development of lymphoma and HTLV-I-associated myelopathy/tropical spastic paraparesis. Skin biopsies from 19 patients with IDH were studied histologically and immunohistochemically using the following antibodies: anti-CD3, CD45RO, CD2...

BACKGROUND/AIMS Intradialytic hypotension (IDH) is a serious and frequent complication of hemodialysis (HD). Thus far, data are scarcely available to assess the impact of first versus subsequent HD sessions of the week in IDH. Therefore, the purpose of this work was to evaluate IDH risk in patients on thrice-weekly HD. METHODS We conducted an analysis of all blood pressure (BP) measurements o...