We have studied the intracellular distribution and internalization kinetics of the granulocyte colony-stimulating factor receptor (G-CSF-R) in living cells using fusion constructs of wild-type or mutant G-CSF-R and enhanced green fluorescent protein (EGFP). Under steady-state conditions the G-CSF-R localized predominantly to the Golgi apparatus, late endosomes, and lysosomes, with only low expr...

<p><em>The leadership of the millennial generation today refers to concept western leadership. In fact, Indonesia is a country that has various noble values nation. One these Ki Hajar Dewantara's According Dewantara, essence education an attempt internalize cultural into child, so child becomes complete human being, both mentally and spiritually. This stage internalization very impo...

Activation of seven-transmembrane receptors is typically followed by desensitization and arrestin-dependent internalization via vesicles that are pinched off by a dynamin collar. Arrestins also scaffold Src, which mediates dynamin-dependent internalization of beta2-adrenergic receptors. Type I mammalian gonadotropin-releasing hormone receptors (GnRHRs) do not rapidly desensitize or internalize ...

let $r$ be a commutative ring. the purpose of this article is to introduce a new class of ideals of r called weakly irreducible ideals. this class could be a generalization of the families quasi-primary ideals and strongly irreducible ideals. the relationships between the notions primary, quasi-primary, weakly irreducible, strongly irreducible and irreducible ideals, in different rings, has bee...

Site-specific mutagenesis has been used to define the sequences required for efficient internalization of the human transferrin receptor. It has previously been shown that the sole cytoplasmic tyrosine, at position 20, is required for efficient internalization. When two other cytoplasmic aromatic residues, the phenylalanines at positions 13 and 23, are substituted with alanines internalization ...

Agonist-induced internalization of G protein-coupled receptors plays an important role in signal regulation. The underlying mechanisms of the internalization of the human neuropeptide Y(2) receptor (hY(2)R), as well as its desensitization, endocytosis, and resensitization are mainly unknown. In the present study we have investigated the role of carboxyl-terminal (C-terminal) Ser/Thr residues an...

We prove the following result: Theorem. Every algebraic distributive lattice D with at most א1 compact elements is isomorphic to the ideal lattice of a von Neumann regular ring R. (By earlier results of the author, the א1 bound is optimal.) Therefore, D is also isomorphic to the congruence lattice of a sectionally complemented modular lattice L, namely, the principal right ideal lattice of R. F...

Authors who report ground reaction force (GRF), free moment (FM), and resultant joint moments usually normalize these variables by division normalization. Normalization parameters include body weight (BW), body weight x height (BWH), and body weight x leg length (BWL). The purpose of this study was to explore the appropriateness of division normalization, power curve normalization, and offset n...

in this paper, we define the notions of ultra and involution ideals in $bck$-algebras. then we get the relation among them and other ideals as (positive) implicative, associative, commutative and prime ideals. specially, we show that in a bounded implicative $bck$-algebra, any involution ideal is a positive implicative ideal and in a bounded positive implicative lower $bck$-semilattice, the not...

in this paper we investigate some hereditary properties of amenability modulo an ideal of banach algebras. we show that if (e) is a bounded approximate identity modulo i of a banach algebra a and x is a neo-unital modulo i, then (e) is a bounded approximate identity for x. moreover we show that amenability modulo an ideal of a banach algebra a can be only considered by the neo-unital modulo...