web based interface is an application which provides facilities to programmer for software development such as code completing and fixing, source code editing and management, automated testing, etc. Software is rapidly moving from the desktop to the Web. The Web provides a generic user interface that allows ubiquitous access, instant collaboration, integration with other online services, and av...

Insulin degradation is a finely tuned process that plays a major role in controlling insulin action and most evidence supports IDE (insulin-degrading enzyme) as the primary degradative agent. However, the biomolecular mechanisms involved in the interaction between IDE and its substrates are often obscure, rendering the specific enzyme activity quite difficult to target. On the other hand, biome...

Transmiss ion e lect ron microscopy and d i f f rac t ion have been used to s tudy the pack ing ar ranqemencs of docosyi mercaptan (CH3(CHl)rtSH,RSH), didocosyl sulf ide (RSR), and didocosyi disulf ide (RSSR) on gold single,cr]€tal foils. The specimens include gold t-rlms in (100) and (11f ) orientatiors. Docosyl mercaptax and didocosyl disulf ide adsorbed on (111) faces assemble in coincidence...

We have analyzed the genetic basis for T cell recognition of an endogenous major histocompatibility complex class II-restricted self peptide. Transgenic mice expressing the influenza virus PR8 hemagglutinin I-Ed-restricted determinant $1 (HA Tg mice) mediate negative selection ofPR8 Sl-specific T cells, but respond to immunization with a virus containing a closely related analogue, $1(Kl13). Se...

We are building an open-source networked system designed and optimized specifically for creating an efficient work atmosphere for relatively small (2 to 20 people) software development groups by offering an easy-to-install, easy-to-use collaborative editing environment.

The insulin-degrading enzyme is responsible for the intracellular proteolysis of insulin. Its gene IDE is located on chromosome 10, in an area with suggestive linkage to type 2 diabetes and related phenotypes. Due to the impact of genetic variants of this gene in rodents and the function of its protein product, it has been proposed as a candidate gene for type 2 diabetes. Various groups have ex...

Vector Quantization (VQ) is a popular image compression technique with a simple decoding architecture and high compression ratio. Codebook designing is the most essential part in Vector Quantization. Linde–Buzo–Gray (LBG) is a traditional method of generation of VQ Codebook which results in lower PSNR value. A Codebook affects the quality of image compression, so the choice of an appropriate co...

Recently, several innovative tools have found their way into mainstream use in modern development environments. However, most of these tools have focused on creating and modifying code, despite evidence that most of programmers’ time is spent understanding code as part of maintenance tasks. If new tools were designed to directly support these maintenance tasks, what types would be most helpful?...

INTRODUCTION Five nucleos(t)ide analogs are used to treat chronic hepatitis B. Ideal nucleos(t)ide analog therapy in chronic hepatitis B patients with kidney transplantation must ensure virological suppression and minimize renal injury. However, resistance to nucleos(t)ide analogs frequently results in virological breakthrough, hepatitis flare, and complicated deterioration of the transplanted ...

BACKGROUND The insulin-degrading enzyme gene (IDE) is a strong functional and positional candidate for late onset Alzheimer's disease (LOAD). METHODOLOGY/PRINCIPAL FINDINGS We examined conserved regions of IDE and its 10 kb flanks in 269 AD cases and 252 controls thereby identifying 17 putative functional polymorphisms. These variants formed eleven haplotypes that were tagged with ten variant...