OBJECTIVE To examine the effect of sperm morphology on embryo development at the chromosomal level. DESIGN Prospective study. SETTING Assisted fertilization center. PATIENT(S) Couples who underwent IVF-PGS cycle, as a result of advanced maternal age, were randomly allocated into two groups: intracytoplasmic sperm injection (ICSI; n = 60) or intracytoplasmic morphologically selected sperm ...

OBJECTIVE To investigate the expression of oocyte-specific linker histone protein (hH1FOO) in human ovaries and its incorporation into sperm chromatin after intracytoplasmic sperm injection (ICSI). DESIGN Laboratory study. SETTING University hospital. PATIENT(S) Human ovarian tissues were obtained from patients at oophorectomy. Human oocytes and embryos were obtained from infertile patien...

OBJECTIVE To compare the karyotype of babies conceived through ICSI with that of naturally conceived babies. DESIGN Prospective controlled study. SETTING The Egyptian IVF-ET Center, Cairo, Egypt. PATIENT(S) Four hundred and thirty babies conceived through ICSI and 430 babies conceived naturally. INTERVENTION(S) ICSI and karyotyping. MAIN OUTCOME MEASURE(S) Abnormal karyotype. RESULT...

There were few reports about infertile women aged 45 and above undergoing IVF/ICSI. We are reporting the case of an aged 49 woman who delivered the twins after ICSI using autologous oocytes by mild ovarian stimulation. The patient who presented with 26-year primary infertility was caused by double fallopian tubes obstruction and man oligoasthenozoospermia. We gave her the treatment with mild ov...

OBJECTIVE To test a newly invented intracytoplasmic sperm injection (ICSI) sperm selection method based on sperm hyaluronic acid (HA) binding. DESIGN Comparison of chromosomal disomy and diploidy frequencies in sperm arising from semen and in HA-bound sperm. SETTING Academic andrology laboratory. PATIENT(S) Men presenting for semen analysis. INTERVENTION(S) Washed sperm fractions of 32 ...

BACKGROUND Outcome data on children born after assisted reproduction treatments are important for both patients and health-care providers. The objective of this study was to determine whether embryo biopsy as performed in PGD has an impact on the health of infants up to 2 months of age. METHODS A prospective comparative follow-up study of children born after PGD and children born after ICSI b...

Introduction: We aimed to determine pregnancy and miscarriage rates following intracytoplasmic sperm injection (ICSI) cycles using retrieved epididymal and testicular sperm in azoospermic men and ejaculated sperm in oligospermic and normospermic men. Materials and Methods: This retrospective study was carried out on 517 couples who underwent ICSI. They included 96 couples with azoospermia and 4...

INTRODUCTION Male infertility caused by azoospermia due to non-reconstructable obstruction or non-obstructive azoospermia can be treated by microsurgical epididymal aspiration (MESA) or testicular sperm extraction (TESE) followed by an intracytoplasmatic spermatozoa injection (ICSI). MATERIAL AND METHODS From 9/93 to 6/01, we carried out 1,025 ICSI procedures with aspirated epididymal or test...

Among infertile couples, 25% involve both male and female factors, while male factor alone accounts for another 25% due to oligo-, astheno-, teratozoospermia, a combination of the three, or even a complete absence of sperm cells in the ejaculate and can lead to a poor prognosis even with the help of assisted reproductive technology (ART). Intracytoplasmic sperm injection (ICSI) has been with us...