Correlated responses to selection for rapid 3 to 6-wk postweaning gain in male mice were estimated for five fat depots weighed at specific degrees of maturity in body weight (37.5, 50.0, 62.5, 75, 87.5 and 100%). Fat pads measured were from regions of the subcutaneous hindlimb, subcutaneous forelimb, epididymides, mesentery and kidneys. At the same degree of maturity, selected mice (M16) were o...

The hairless mouse strain NS:Hr/ICR was examined as a potential small animal model of Helicobacter pylori colonization, adherence to gastric epithelial cells in vivo, and gastritis. Among several small animals tested, NS:Hr/ICR mice proved to be the most highly susceptible to H. pylori infection. Challenge with clinical isolates of H. pylori consisting of either phenotype I or II (VacA and CagA...

The inhibitory effects of Asparagus cochinchinensis against inflammatory response induced by lipopolysaccharide (LPS), substance P and phthalic anhydride (PA) treatment were recently reported for some cell lines and animal models. To evaluate the hepatotoxicity and nephrotoxicity of A. cochinchinensis toward the livers and kidneys of ICR mice, alterations in related markers including body weigh...

OBJECTIVES We investigated the genotoxicity of two chemicals, methyl formate and 2-methylbutane, using male ICR mice bone marrow cells for the screening of micronucleus induction. Although these two chemicals have already been tested numerous times, a micronucleus test has not been conducted and the amounts used have recently been increased. METHODS 7 week male ICR mice were tested at dosages...

Currently, the metabolic syndrome (MS) is occurring at growing rates worldwide, raising extensive concerns on the mechanisms and therapeutic interventions for this disorder. Herein, we described a novel method of establishing MS model in rodents. Male Institute of Cancer Research (ICR) mice were fed with high-fat-high-fructose (HFHF) diet or normal chow (NC) respectively for 12 weeks. Metabolic...

BACKGROUND The vestibular lesion (VL) is required to examine the physiological function of the vestibular system in animals. Toxic chemicals or electrical apparatus have been used for the VL, however, they are not ideal as they have low specificity, and can result in unintended damage, and systemic toxic effect. NEW METHOD Localized vibration-induced VL, using an ultrasonicator, is expected t...

Lee, W. C., H. C. Wen, C. P. Chang, M. Y. Chen, and M. T. Lin. Heat shock protein 72 overexpression protects against hyperthermia, circulatory shock, and cerebral ischemia during heatstroke. J Appl Physiol 100: 2073–2082, 2006; doi:10.1152/japplphysiol.01433.2005.— This study extends our earlier studies in rats by applying our heatstroke model to a new species. Additionally, transgenic mice are...

Using a method recently developed at our laboratory, we determined the initial rate of Pseudomonas aeruginosa replication in the lung under different experimental conditions. Mice were exposed to aerosols containing mixtures of a temperature-sensitive (ts) mutant of P. aeruginosa and its parental wild type (wt). The changes in the ratio of ts:wt were determined by quantitatively culturing homog...

Parent-of-origin-specific expression at imprinted genes is regulated by allele-specific DNA methylation at imprinting control regions (ICRs). This mechanism of gene regulation, where one element controls allelic expression of multiple genes, is not fully understood. Furthermore, the mechanism of gene dysregulation through ICR epimutations, such as loss or gain of DNA methylation, remains a myst...

A large proportion of follicles are lost during the initial ischemia that occurs after transplantation of ovarian tissues. Thus, the effect of hyperbaric oxygen therapy (HBO) on the follicular loss of ovarian tissues after transplantation was examined in mice. Ovarian slices from ICR mice were transplanted under the kidney capsule in ovariectomized ICR. Hyperbaric oxygen with 100% oxygen was in...