A simple, specific, sensitive, precise stability-indicating high-performance liquid chromatography method for determination of Risperidone in tablet dosage form was developed and validated. A Waters Xterra RP8 column (250*4.6 mm, 5 μ) in isocratic mode, with mobile phase consisting of a mixture of solution (10 mM potassium dihydrogen phosphate, pH 3.5 ± 0.05): acetonitrile: methanol (65:20:15) ...

Atropine (AT) and oximes, alone or in combination, have been proven greatly valuable therapeutics in the treatment of organophosphates intoxications. An injectable mixture of AT and obidoxime (OB) was formulated for the administration by automatic self-injector. The aqueous single dose solution contained 275 mg obidoxime chloride and 2.5 mg atropine sulfate per 1 mL (220 mg and 2 mg per 0.8 eff...

There have been many reports about the prognosis and risk factors of stroke recurrence following brain infarction (BI). However, little is known about the stroke recurrence after primary intracerebral hemorrhage (PICH). Therefore, we explored the recurrent stroke patients after initial PICH retrospectively, to reveal the critical factors of stroke recurrence. Acute BI (n=4013) and acute PICH pa...

Intracranial hemorrhage (ICH) is the most feared and devastating complication of anticoagulant treatment, leading to death or disability in two thirds of cases. Once ICH occurs, the decision of whether to resume anticoagulation is a true therapeutic dilemma that requires balancing the competing risks of hematoma growth or recurrent ICH and disabling thromboembolic events. Although the risk of t...

BACKGROUND AND PURPOSE We aimed to develop a risk score (intracerebral hemorrhage-associated pneumonia score, ICH-APS) for predicting hospital-acquired stroke-associated pneumonia (SAP) after ICH. METHODS The ICH-APS was developed based on the China National Stroke Registry (CNSR), in which eligible patients were randomly divided into derivation (60%) and validation (40%) cohorts. Variables r...

A simple, precise and accurate RP-HPLC method has been described for estimation of niacinamide and salicylic acid in semi-solid dosage form. The separation is done by using column Oyster BDS C (250 mm × 4.6 mm) at 25°C and 74:26 (v/v) water: methanol as mobile phase at flow rate of 1 mL/min and pH adjusted to 3 with triethylamine and glacial acetic acid. Detection is carried out at 280 nm. The ...

INTRODUCTION Intracerebral hemorrhage (ICH) at high altitude is not well understood to date. This study investigates the effects of high altitude on ICH, and examines the acute neuroprotection of hyperbaric oxygen (HBO) therapy against high-altitude ICH. METHODS Minipigs were placed in a hypobaric chamber for 72 h before the operation. ICH was induced by an infusion of autologous arterial blo...

BACKGROUND AND PURPOSE 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, have been associated with improved outcome after ischemic stroke and subarachnoid hemorrhage but an increased risk of incident intracerebral hemorrhage (ICH). We investigated (1) whether statin use before ICH was associated with functional independence at 90 days, and (2) whether survivors e...

We have sequenced the chicken interleukin-1beta-converting enzyme (ICE) and ced-3 homolog (Ich-1) cDNA, and evaluated Ich-1 mRNA expression in the hen ovary during follicle development. While two alternatively spliced forms of Ich-1, Ich-1L and Ich-1S, were amplified by PCR from an embryonic chicken cDNA library, only the Ich-1L form was found to be expressed in adult ovarian granulosa and thec...

BACKGROUND The ICH score is a validated tool for predicting 30-day morbidity and mortality in patients with intracerebral hemorrhage. AIMS AND/OR HYPOTHESIS The aim of this study is to determine if the ICH score calculated 24 hours after admission is a better predictor of mortality than the ICH score calculated on admission. METHODS Patients presenting to our center with ICH from 7/08-12/10...