Hypoxia-inducible factors (HIFs) and cancer stem cells (CSCs) are two challenging causes of radiotherapy chemotherapy resistance, leading to most cases failure recurrence in breast therapy. This study was conducted investigated the inhibitory effect combination therapy with doxorubicin (an anthracycline) FM19G11 HIF inhibitor) on MCF-7 their CSC-like (CSC-LCs). CSC-LCs a CD44+/CD24- phenotype w...

Backround. There is increasing evidence of the role of hypoxia or pseudohypoxia in tumorigenesis, including pheochromocytoma (PHEO) and paraganglioma (PGL). (Pseudo)hypoxia leads to activation of hypoxia-inducible transcription factors (HIFs) and thus, promotes the transcription of hypoxia-responsive genes which are involved in tumorigenesis. Recently identified is a new syndrome consisting of ...

In the lung, acute reductions in oxygen lead to hypoxic pulmonary vasoconstriction, whereas prolonged exposures to hypoxia result in sustained vasoconstriction, pulmonary vascular remodeling, and the development of pulmonary hypertension. Data from both human subjects and animal models implicate a role for hypoxia-inducible factors (HIFs), oxygen-sensitive transcription factors, in pulmonary va...

Echinomycin (EKN), an inhibitor of hypoxia-inducible factor (HIF)-1 DNA-binding activity, has been implied as a possible therapeutic agent in ischemic diseases. Here, we assess EKN hypoxia-driven responses vitro using human primary adult retinal pigment epithelium cells (aRPE) and endothelial (hREC), vivo the laser-induced mouse choroidal neovascularization (CNV) model. Effects on hypoxia-media...

Vasculogenic mimicry (VM) is the release of angiogenic factors from tumor cells, leading to morphological changes, migration and proliferation vascular endothelial ultimately neovascularization. The presence VM has been identified in breast cancer, formation also gives cancer a poor prognosis such as drug resistance metastasis. authors focus on role PI3K/Akt signaling pathway, hypoxia-inducible...