The Cyanophages are the phages infecting cyanobacteria. They are potential agents for the horizontal gene transfer. The complete genome of 10 known Cyanophages deciphered the presence of various gene sequences for hypothetical proteins whose functions are not yet understood. Our attempt is to predict the structure and function of these hypothetical proteins by the application of computational m...

Helicobacter pylori (H. pylori) have a unique ability to survive in extreme acidic environments and to colonize the gastric mucosa. It can cause diverse gastric diseases such as peptic ulcers, chronic gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma, gastric cancer, etc. Based on genomic research of H. pylori, over 1600 genes have been functionally identified so far. However, H. pyl...

In the real world, there are some domain knowledge discovery problems that can be formulated into knowledge-based planning problems, such as chemical reaction process and biological pathway discovery problems (Khan et al. 2003). A view of these domain problems can be re-cast as a planning problem, such that initial and final states are known and processes can be captured as abstract operators t...

Many-multiplet (MM) method [1] applied to three inhomogeneous samples of Keck/HIRES quasar absorption spectra gives a shift in the value of the fine-structure constant of ∆α/α = (−5.4± 1.2)× 10−6 in the redshift range 0.2 < z < 3.7 [2]. The 1 σ error claimed in [2] is, however, much too small and cannot be maintained by current observations of quasars. We present a modified MM method to set an ...

After several decades of academic research on the contingent valuation (CV) method a consistent behavioral explanation of ‘hypothetical bias’ is still lacking. Based on evidence from economics, economic psychology and the political sciences, I propose an explanation that is based on two simple working hypotheses about respondent behaviour in contingent valuation surveys. The first hypothesis is...

In this paper, I argue that science education research and curriculum development efforts in Non-western countries can benefit by adopting a constructivist view of science and science learning. The past efforts at transferring curricula from the West, and local development projects that result in curricula only marginally different from Western curricula, stem from an acultural view of science....

Hypothetical proteins often with unknown functions . Mycobacterium tuberculosis H37Rv has a very large number of such proteins , which can be exploited as drug target as the bacterium became more virulent with developing antibiotic resistance to first line and second line of drugs . Some hypothetical proteins (290 proteins) were studied from different aspects related to find the druggable prote...

Manufacturing flexibility is a competitive weapon for surviving today’s highly variable and volatile markets. It is critical therefore, to select the appropriate type of flexibility for a given manufacturing system, and to design effective strategies for using this flexibility in a way to improve the system performance. This study focuses on full routing flexibility which includes not only alte...

Abstract The problem that how many protein-coding genes exist in Aeropyrum pernix K1 genome has confused many scientists since 1999. In this paper, we attempt to re-identify the protein-coding genes in this genome by proposing a modified method based on I-TN curve. Consequently, all of the 727 experimentally validated protein-coding genes and 726 of the corresponding negative samples are correc...

BACKGROUND Toxoplasma gondii is an obligate intracellular zoonotic parasite of the phylum Apicomplexa which infects a wide range of warm-blooded animals, including humans. In this study in-vivo induced antigens of this parasite was investigated using in-vivo induced antigen technology (IVIAT) and pooled sera from patients with serological evidence of acute infection. METHODS The pooled sera w...