Cardiovascular problems have been haunting human populations for a long time with no specific cure. It is believed that a shift in the eating, and physical habits might have paved the way for the alarming increase in cardiovascular diseases. Increase in the lipid level has been pinpointed as an important risk factor. Hence epidemiological and clinical studies were undertaken throughout the worl...

Nutraceuticals are food components or active ingredients present in foods and used in therapy. This article analyzes the characteristics of the molecules with a lipid-lowering effect. The different nutraceuticals may have different mechanisms of action: inhibition of cholesterol synthesis primarily through action on the enzyme HMG-CoA reductase (policosanol, polyphenols, garlic and, above all, ...

71 Received December 19, 2014; revised and accepted April 24, 2015. Published online May 16, 2015; doi: 10.1620/tjem.236.71. Correspondence: Xiangdong Gao, School of Life Science and Technology, China Pharmaceutical University, Tongjiaxiang 24, Nanjing 210009, Jiangsu, P.R.China. e-mail: [email protected] Hypoglycemic, Hypolipidemic and Antioxidant Effects of Peptides from Red Deer Antlers i...

Oleogum resin (known as guggul) from the guggul tree, Commiphora mukul, found in India, Bangladesh, and Pakistan, has been used to treat various diseases including hyper-cholesterolemia, atherosclerosis, rheumatism, and obesity over several thousands of years. Guggulsterone isolated from guggul has been identified as the bioactive constituent responsible for guggul's therapeutic effects. Since ...

Previous work in this laboratory indicated that sulfursubstituted fatty acid analogues, 1 . lO-bis(carboxymethylthio)decane and alkylthioacetic acid, both non-@-oxidizable compounds, and the @-oxidizable alkylthiopropionic acid (1) caused, to different extents, dase-related hepatomegaly and proliferation of pemxi"es and enhanced pervxisomal fatty acid 8-oxidation. In the present study, treatmen...

Certain phthalate esters and hypolipidemic agents are known to induce morphological and biochemical changes in the liver of rodents, which have been associated with an increased incidence of hepatocellular tumors in these species. There is evidence that hypolipidemic agents do not induce these effects in either subhuman primates or man. The oral and intraperitoneal administration of di(2-ethylh...