Background and Objective: Prolonged use of hyperosmolar solution associated with mortality. Hypertonic sodium lactate as a new sodium-based does not yet have an evidence base that states long-term is safe in increasing ICP. Knowing the effect hypertonic on alterations level male wistar rats compared to mannitol Subject Method: This research animal experimental laboratory study using simple rand...

Pyolytics are drugs that dissolve thick pus when applied topically. This group of was discovered in early 21st century Russia as a result successful repurposing antiseptics hydrogen peroxide, sodium bicarbonate and chloride from to pyolytics. Prior this watershed event pharmacy, the problem effective treatment purulent diseases had not been solved. The fact is before various mainly disinfectant...

BACKGROUND Sodium lactate has been shown to improve hemodynamics and avoid fluid overload. The objective of this study was to confirm a beneficial effect on fluid balance with sodium lactate infusion and to specify whether the advantage of lactate is related to a negative chloride balance, its particular metabolism, or simply its energy load. METHODS This was an interventional, randomized, op...

Uncompensated heart failure (UHF) is a leading cause of hospitalization. The available drugs to treat acute UHF include inotropes, diuretics and vasodilators. In recent years, hypertonic saline (HTS) has emerged as a new potential therapy for refractory heart failure, usually in association with high doses of diuretics. However, there have been no reports describing the use of HTS as a first-li...

It was discovered by Polge, Smith & Parkes (1949) that spermatozoa could be frozen and thawed without loss of motility if glycerol was included in their suspending medium. Following this discovery the spermatozoa of the domestic fowl (Polge, 1951), ofthe bull (Polge & Rowson, 1952) and ofthe herring (Blaxter, 1953) have been preserved without loss of function for long periods in the frozen stat...

The purpose of this study was to investigate the acute blood pressure (BP) and hemodynamic effects of sodium chloride (3% intravenous solution). Although many studies link a change in dietary sodium to a change in BP, few consider the effects of sodium concentration in the blood on BP. We hypothesized that an intravenous sodium load would increase BP, and we quantified alterations in cardiac ou...

OBJECTIVE To determine if Ringer's lactate is superior to 0.9% sodium chloride solution for resolution of acidosis in the management of diabetic ketoacidosis (DKA). DESIGN Parallel double blind randomized controlled trial. METHODS Patients presenting with DKA at Kalafong and Steve Biko Academic hospitals were recruited for inclusion in this study if they were >18 years of age, had a venous ...

The effects of acetazolamide (Diamox), ouabain, and amiloride on chloride movements through the isolated, nonshort-circuited Rana esculenta skin were investigated at different external NaCl concentrations. From hyposmotic solutions of low NaCl concentration (2 mM), two principal components of the chloride uptake may be distinguished: one dependent on the osmotic water flux and the other inhibit...