STUDY QUESTION What is the behavioral mechanism underlying the response of human spermatozoa to a temperature gradient in thermotaxis? SUMMARY ANSWER Human spermatozoa swim up a temperature gradient by modulating their speed and frequencies of hyperactivation events and turns. WHAT IS KNOWN ALREADY Capacitated human spermatozoa are capable of thermotactically responding to a temperature gra...

Carbazole derivatives have gained a lot of attention in medicinal chemistry over the last few decades due to their wide range biological and pharmacological properties, including antibacterial, antitumor, antioxidant, anti-inflammatory activities. The therapeutic potential natural, semi-synthetic or synthetic carbazole-containing molecules has expanded considerably owing role pathogenesis devel...

Abstract Autoinflammation with infantile enterocolitis (AIFEC) is one of the emerging life-threatening diseases caused by inborn errors NLRC4 inflammasome. The pathogenicity AIFEC remains largely unknown and standard therapy lacking due to rare patient cases high mortality. To fill gap, it urgent set up an effective animal model for this disease. We have recently generated a loxP-flanked V341A ...