Ser (= /3-hydroxy Ala) belongs to the proteinogenic amino acids while other /3-hydroxy amino acids prevail in bacterial peptidic metabolites, often acting as Fe3+ chelating ligands. Thus, ß-hydroxy Asp is frequently encountered in the Pseudomonas siderophores (pyoverdins) [1], /3-Hydroxy Leu and 3-hydroxy-3-methyl Pro were recently found in a depsipeptide from Streptomyces sp. [2], L-Erythro-ß-...

N-Hydroxy-2-acetylaminofluorene (N-hydroxy-AAF), in conjugated form, was identified as a urinary metabolite of 2-acetylaminofluorene (AM') in male mongrel dogs. This metabolite was isolated and characterized in crystalline form. 7-Hydnoxy AM', in conjugated form, and AM? were also found in the urine of dogs fed AAF; no 1-, 3-, or 5-hydroxy-AAF was detected. The ingestion of N-hydroxy-AAF led to...

Here we evaluated the levels of lipid oxidation products, fatty acids, ascorbic acid and colour Porphyra Ulva after oven-drying at 40 °C, during subsequent storage for ?370 days under light, semi-light dark conditions. Part seaweed was pre-soaked in freshwater or pre-coated with a whey protein mixture. Controls consisted freeze-dried seaweeds. Throughout there moderate development oxidation-der...

Urinary N-hydroxy metabolites of the bladder carcinogens, 2-aminofluorene and 4-aminobiphenyl, were examined for the induction of unscheduled DNA synthesis (UDS) in urothelial cells of several susceptible species. N-Hydroxy-2-aminofluorene, N-hydroxy-2-acetylaminofluorene (N-OH-AAF), N-hydroxy-4-aminobiphenyl, N-hydroxy-4-acetylaminobiphenyl, and the N-glucuronides of these two hydroxylamines i...

in this work needle like hydroxy apatite were synthesized in a reverse microemulsion droplets of water in cyclohexane, separated by a cationic surfactant and co-surfactant, in the presence of na-polyacrylate (paa) as an anionic polyelectrolyte. characterization of the as formed hap nanoparticles at the room temperature were carried out by x-ray diffraction (xrd) and fourier transform infrared s...

in this study, the adsorption of 4-hydroxy phenyl-azobenzene on the surface of (4, 0) zigzag open-end boron nitride nanotube (bnnt) has been investigated by quantum calculations. in order to find the preferred adsorption site, different positions and orientations were considered. the impacts of donor-acceptor electron delocalization on the structural and electronic properties and reactivity of ...

Lanthanide ions, Ln(III), are of interest in the treatment of bone density disorders because they are found to accumulate preferentially in bone (in vivo), have a stimulatory effect on bone formation, and exhibit an inhibitory effect on bone degradation (in vitro), altering the homeostasis of the bone cycle. In an effort to develop an orally active lanthanide drug, a series of 3-hydroxy-4-pyrid...

The structure-activity relationships between flavonoids and their tracheal relaxant action are little known. In the present study, 26 natural and synthetic flavonoids, divided into the five classes of flavones, flavonols, flavanones, isoflavones, and chalcones, were tested, and their IC (50) values were determined. The IC (50) values of these five classes indicated that flavones were more poten...

Several aspects of the metabolism of hydroxy fatty acids were studied in dogs with steatorrhea resulting from an experimentally produced jejunal blind loop. In these animals hydroxy acids were present in the stool in amounts far above normal. These acids disappeared from the feces during tetracycline administration and after exclusion of the blind loop-both procedures that corrected the steator...