Aromatic amines can be metabolized by N-acetylation and N-hydroxylation to hydroxamic acids; these subsequently are conjugated to form the N,O-sulfonate and N,O-glucuronide conjugates. The N,O-sulfonates are highly labile metabolites that generate reactive intermediates involved in the covalent binding of the parent compound to protein, RNA and DNA, as well as to low molecular compounds like gl...

1. Acylation of 2-(N-hydroxyacetamido)fluorene and several other aromatic hydroxamic acids by carbamoyl phosphate was studied and compared with the acylating activity of acetyl-CoA. Acetyl phosphate was also studied. 2. The carbamoylation reaction had a pH optimum of 4.5. The reaction had a lag period of 1h and was then linear for 4h. This linearity ranged between 0.5mm- and 8mm-carbamoyl phosp...

The N-dealkylation reactions of benzamides occur naturally in living organisms but chemical methods remain poorly developed. So far, light-induced variants these processes have been restricted to amides containing secondary N-alkyl groups or required pre-functionalization the starting material. Here, we present a direct, controllable tertiary and possessing primary alkyl substituents at N-atom....

The functionalisation of macrocyclic p-tertbutylcalix[4]arenes at the lower rim with hydroxamic acid and proline hydroxamic acid groups gives the calixarenes chelating properties similar to siderophores. The (1)H NMR spectrum of p-tertbutylcalix[4]arene tetrahydroxamic acid shows a broad band at 10.8 ppm in DMSO-d(6) attributed to NHOH protons. Diffuse reflectance spectral analysis of PVC membr...

We have studied the adsorption of three organic molecules onto different surfaces of goethite a-FeO(OH) using atomistic simulation techniques. New interatomic potentials for the interaction between goethite and the organic molecules were developed. In the majority of cases the organic molecules were found to be capable of forming a coordinate bond via their carbonyl oxygen atom with a surface i...

Dithiomaleimides (DTMs) with alkyl substituents are shown to be a novel class of highly emissive fluorophores. Variable solubility and further functionalization can easily be tailored through the choice of N and S substituents. Inclusion of a DTM unit into a ROP/RAFT initiator or insertion into the disulfide bond of salmon calcitonin (sCT) demonstrates the utility for fluorescent labeling of po...