A diagnostic flow chart is presented for use in case of perinatal death or still birth with non-immune hydrops fetalis, visceral effusions, or increased nuchal translucency. Immunohistochemical staining with CD-31, CD-34, D2-40, and smooth muscle actin is recommended.

We report a case of an infant with congenital diaphragmatic hernia (CDH) and hydrops fetalis who died from hypoxic respiratory failure. Autopsy revealed type B interrupted aortic arch (IAA). Microarray revealed a female karyotype with deletion of chromosome 1p21.1p12. There may be an association between 1p microdeletion, CDH, and IAA.

Right sided Congenital Diaphragmatic Hernia (CDH) has been previously associated with venous or lymphatic obstruction of vessels by the herniated liver. We report an unusual case of direct cardiac atrial compression by the liver causing limitation of preload and resultant fetal non-immune hydrops fetalis.

Pyruvate kinase deficiency was diagnosed in an infant by umbilical vessel sampling at 30 weeks' gestation. Although three previous hydropic siblings had been stillborn or died in the neonatal period, this infant survived with transfusion dependent haemolytic anaemia. Prompt fetal diagnosis of pyruvate kinase deficiency is feasible and allows better management of hydrops fetalis due to this diso...

Recurrent non-immune fetal hydrops (NIH) has been reported in the literature but it’s a very rare entity. It has been postulated to be related to a recessive gene. We report a case of recurrent non immune fetal hydrops in a multigravida with no medical history of note. She presented in her current pregnancy with a significant history of having 2(out of 3) previous pregnancies affected by hydrop...