This work reports the design and synthesis of amino acid-based hyperbranched polymers via the combination of self-condensing vinyl polymerization (SCVP) and reversible addition–fragmentation chain transfer (RAFT) polymerization from tert-butyl carbamate (Boc)-L-valine acryloyloxyethyl ester (Boc-Val-HEA) and S-(4-vinyl)benzyl S’-butyltrithiocarbonate (VBBT) with variable degrees of branching (D...

This work reports the design and synthesis of amino acid-based hyperbranched polymers via the combination of self-condensing vinyl polymerization (SCVP) and reversible addition–fragmentation chain transfer (RAFT) polymerization from tert-butyl carbamate (Boc)-L-valine acryloyloxyethyl ester (Boc-Val-HEA) and S-(4-vinyl)benzyl S’-butyltrithiocarbonate (VBBT) with variable degrees of branching (D...

Swelling agents are hydrophilic crosslinked polymers, which swell from 10 to 1,000 times their own weight when placed in an aqueous medium. Depending on their swelling properties, these materials have been exploited in developing three different classes of materials in pharmaceutical industries, i.e. swellable matrices, superdisintegrants and swelling devices. Since their development, these pha...

Here we report the modification of an amphiphilic antibacterial polynorbornene, Poly3, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and postpolymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices ranging f...