Herein, we report the synthesis of platinum(II) complex bearing 3?-aminothiocyclohexanespiro-5?-hydantoin as ligand. The was characterized by IR, NMR spectral analyses, elemental analyses and density functional theory (DFT) calculations. Cytotoxicity inhibitory potential on xanthine oxidase (XO) were evaluated performed docking cytotoxic activities (1), its Pt(II) (2), thiocyclohexanespiro-5?-h...

A model for computing image ow in image sequences containing a very wide range of instantaneous ows is proposed. This model integrates the spatio-temporal image derivatives from multiple temporal scales to provide both reliable and accurate instantaneous ow estimates. The integration employs robust regression and automatic scale weighting in a generalized brightness constancy framework. In addi...

Phenytoin (Diphenyl Hydantoin or Dilantin) is highly effective and widely prescribed anticonvulsant agent used in the treatment of grand mal and psychomotor epilepsy. Phenytoin has been used to treat thought, mood and Behavior disorders, cardiovascular disorders, Neuro muscular disorders, gastrointestinal disorders, Endocrine disorders.

A synthetic scaffold that mimics a peptide β-strand has been designed and synthesised based on a 1,3-phenyl-linked hydantoin oligomer. The conformational preferences of this oligomer were investigated using molecular modelling and solution NMR experiments and suggest a planar conformation that accurately mimics the i, i + 2 and i + 4 residues of a peptide β-strand.

In the title compound, C15H18N2O2S, the 2,3-di-hydro-1-benzo-thio-pyran ring adopts a sofa conformation and the hydantoin ring is twisted with respect to the benzene ring at 78.73 (17)°. In the crystal, pairs of N-H⋯O hydrogen bonds link the mol-ecules into inversion dimers.

We report a patient with fetal hydantoin syndrome and hypoplastic left heart. Only three other cases with this association have been described. This case also highlights the importance genetic variation plays in the phenotypic variability of teratogens and the importance of good prenatal care to minimize risk of teratogenesis.