Although cognitive neuroscience has made remarkable progress in understanding the involvement of the prefrontal cortex in human memory, the necessity of the orbitofrontal cortex for key competencies of working memory remains largely unexplored. We therefore studied human brain lesion patients to determine whether the orbitofrontal cortex is necessary for working memory function, administering s...

Managing occupational safety in any kind of industry, especially in processing, is very important and complex. This paper develops a new method for occupational risk assessment in the presence of uncertainties. Uncertain values of hazardous factors and consequence frequencies are described with linguistic expressions defined by a safety management team. They are modeled with fuzzy sets. Consequ...

Although neuroscience has made remarkable progress in understanding the involvement of prefrontal cortex (PFC) in human memory, the necessity of dorsolateral PFC (dlPFC) for key competencies of working memory remains largely unexplored. We therefore studied human brain lesion patients to determine whether dlPFC is necessary for working memory function, administering subtests of the Wechsler Mem...

commentary equal, or greater, clinical relevance. 5 Thus far, a majority of therapeutic agents proposed for treatment of neurodegenerative disease are secreted trophic factors such as insulin-like growth factor 1 and glial cell line–derived neurotrophic factor. 29 Because most trophic factors are typically secreted by glia, it is easy to envision that rAAV-mediated overexpres-sion of trophic fa...

Visual working memory (VWM) is the ability to maintain visual information in a readily available and easily updated state. Converging evidence has revealed that VWM capacity is limited by the number of maintained objects, which is about 3 - 4 for the average human. Recent work suggests that VWM capacity is also limited by the resolution required to maintain objects, which is tied to the objects...

1998). This minireview briefly considers PET and fMRI Charlestown, Massachusetts 02129 evidence regarding the role of prefrontal cortex in epi-Department of Psychology sodic memory and highlights the parallels between Harvard University these results and those from studies of working memory. Cambridge, Massachusetts 02138 Two patterns are emphasized. First, studies of episodic memory suggest th...

We review a program of research that uses neuroimaging techniques to determine the functional and neural architecture of human working memory. A first set of studies indicates that verbal working memory includes a storage component, which is implemented neurally by areas in the left-hemisphere posterior parietal cortex, and a subvocal rehearsal component, which is implemented by left-hemisphere...

Measurements of dangerous, harmful and annoying factors in the working environment are used to assess occupational risk. Surveys on workers’ subjective perception of risk are used, too. This study aimed to compare subjective assessment of work-related factors with their objective measurements and a national database on occupational risk. Spearman’s correlation analysis, stepwise regression anal...