Stem cells are unique that have the ability to differentiate into with specific functions and renew themselves produce new stem cells. One type of actively studied is Spermatogonial Cells (SSC). SSC a unipotent cell develops spermatozoa in mammalian testis. can be transplanted male testis recipients improve genetic quality livestock propagate valuable livestock. transplantation procedure starte...

This review looks into the phylogeny of spermatogonial stem cells and describes their basic biological features. We are focusing on species-specific differences of spermatogonial stem cell physiology. We propose revised models for the clonal expansion of spermatogonia and for the potential existence of true stem cells and progenitors in primates but not in rodents. We create a new model for the...

Germ cells are thought to exhibit a unique DNA damage response that differs from that of somatic stem cells, and previous studies suggested that Trp53 is not involved in the survival of spermatogonial stem cells (SSCs) after irradiation. Here, we report a critical role for the Trp53-Trp53inp1-Tnfrsf10b pathway during radiation-induced SSC apoptosis. Spermatogonial transplantation revealed that ...

Cryopreservation of spermatozoa, oocytes and embryos, as well as somatic cells or cell lines for cloning from cells, are all options for the long-term storage of unique genotypes and endangered species. Spermatozoal cryopreservation and storage currently require liquid nitrogen or ultralow refrigeration-based methods for long- or short-term storage, which requires routine maintenance and extens...

OBJECTIVE To study whether acute lymphoblastic leukemia (ALL) cells survive in a human testicular cell culture system. DESIGN Experimental laboratory study. SETTING Reproductive biology laboratory, academic medical center. PATIENT(S) Acute lymphoblastic leukemia cells from three patients and testicular cells from three other patients. INTERVENTION(S) Acute lymphoblastic leukemia cells w...