Heterogeneity of carcinoma-associated fibroblasts (CAF) has long been recognized, but the functional significance remains poorly understood. Here, we report the distinction of two CAF subtypes in oral squamous cell carcinoma (OSCC) that have differential tumor-promoting capability, one with a transcriptome and secretome closer to normal fibroblasts (CAF-N) and the other with a more divergent ex...

this study was conducted to examine if allergic contact dermatitis (acd) alters the expression of mmps in human dermal fibroblasts. fibroblasts are the primary source for mmp and matrix production in skin. mmps are known to involve in a number of physiological and pathological processes. some published data indicated a gelatinase-like activity in acute and chronic phases of allergic contact der...

Amelotin (AMTN) is a secretory calcium-binding phosphoprotein controlling the adhesion of epithelial cells to tooth surface, forming protective seal against oral cavity. It can be proposed that signals released upon dentinolysis increase AMTN expression in periodontal cells, thereby helping preserve seal. Support for this assumption comes from our RNA sequencing approach showing gingival fibrob...

Polynucleotides (PN) have long been known as an effective supportive therapy for wound healing. The present study investigated whether a hydrogel formulation containing PN and hyaluronic acid (PN + HA) could promote healing in vitro model of gingival fibroblasts. promoted cell growth viability assessed by different assays, HA, though not significantly further increasing compared to PN, supporte...

background: the multifunctional transforming growth factor beta (tgf-β) is a glycoprotein that exists in three isoforms. tgf-β3 expression increases in fetal wound healing and reduces fibronectin and collagen i and iii deposition, and also improves the architecture of the neodermis which is a combination of blood vessels and connective tissue during wound healing. fibroblasts are key cells in t...

BACKGROUND Recent studies have revealed that destruxins (Dtx) have potent cytotoxic activities on individual cancer cells, however, data on oral cancer cells especial human are absent. METHODS Destruxin B (DB) was isolated and used to evaluate the selective cytotoxicity with human oral cancer cell lines, GNM (Neck metastasis of gingival carcinoma) and TSCCa (Tongue squamous cell carcinoma) ce...

Rac proteins, members of the Rho family small GTP-binding have been implicated in transducing a number signals for various biological mechanisms, including cell cytoskeleton organization, transcription, proliferation, migration, and cancer motility. Among human cancers, proteins are highly activated by either overexpression genes, up-regulation protein, or mutations that allow protein to elude ...