نتایج جستجو برای: human igg

تعداد نتایج: 1668481  

2002
Gerburg M. Spiekermann Patricia W. Finn E. Sally Ward Jennifer Dumont Bonny L. Dickinson Richard S. Blumberg Wayne I. Lencer

Mucosal secretions of the human gastrointestinal, respiratory, and genital tracts contain the immunoglobulins (Ig)G and secretory IgA (sIgA) that function together in host defense. Exactly how IgG crosses epithelial barriers to function in mucosal immunity remains unknown. Here, we test the idea that the MHC class I–related Fc-receptor, FcRn, transports IgG across the mucosal surface of the hum...

Journal: :The Journal of Experimental Medicine 2002
Gerburg M. Spiekermann Patricia W. Finn E. Sally Ward Jennifer Dumont Bonny L. Dickinson Richard S. Blumberg Wayne I. Lencer

Mucosal secretions of the human gastrointestinal, respiratory, and genital tracts contain the immunoglobulins (Ig)G and secretory IgA (sIgA) that function together in host defense. Exactly how IgG crosses epithelial barriers to function in mucosal immunity remains unknown. Here, we test the idea that the MHC class I-related Fc-receptor, FcRn, transports IgG across the mucosal surface of the hum...

2005
F. Gomez P. Chien M. King. P. McDermott. A. I. Levinson M. D. Rossman A. D. Schreiber

Monocyte and macrophage Fc. receptors are important components in the recognition of IgG-coated cells and lgG-containing immune complexes. Two proteins have been identified on human peripheral blood monocytes that can function as Fc. receptors. Fc7Rl (70 Kd) and Fc. Rll (40 Kd). We studied the role of Fc.,RI and Fc.,RII on human monocytes by examining their binding of lgG-sensitized cells (huma...

2010
Fatemeh Hajighasemi Fazel Shokri

Different IgG subclass profiles are produced in response to different antigenic stimuli in a variety of diseases. IgG subclass levels may reflect disease severity. Quantification of IgG subclasses depends on the availability of specific Monoclonal antibodies (MAbs). In the present study seven hybridoma clones producing MAbs reactive with multiple subclasses of human IgG were established. Spleno...

Journal: :Clinical science and molecular medicine 1977
A H Balfour E A Jones

1. To investigate the relative degree. to which human IgG and other plasma proteins bind to cell membranes of the full-term human placenta, suspensions of membranes mixed with radio-iodinated proteins were incubated at pH 6.5 and subjected to Sepharose 2B column chromatography. The amount of labelled protein associated with membrane protein in membrane-containing fractions of the eluate was the...

Journal: :iranian biomedical journal 0
طاهره موسوی tahereh mousavi bruce mazer مجید طبیانیان majid tebianian

the link between il-13 and bronchial hyper-responsiveness has brought this cytokine as a potential therapeutic target for asthma and allergic diseases. at the present study, we address the role of b cell derived il-13 in the ige and other immunoglobulin development. antisense oligo for human il-13 m-rna was used to study ige down regulation. human b-lymphocytes were purified by positive selecti...

Journal: :medical journal of islamic republic of iran 0
mh sanati from the national research center for genetic engineering and biotechnology, tehran, i. r. iran pr carnegie the biotechnology research grpup, murdoch university, western australia 6150, australia

when pooled immunoglobulin g (igg) from patients with multiple sclerosis (ms) was used to probe a human fetal spinal cord λgt 11 cdna library, the igg was found to bind to a predicted epitope of human mitochondrial nd4 sequence. to investigate the involvement of the nd4 as an autoantigen in ms, we determined the presence of specific antibody in the serum of ms patients and serum samples of some...

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