Iran has performed Health Transformation Plan (HTP) from 2014 to obtain its defined goals. This study assesses and compares university non-university hospitals’ efficiency productivity in Kerman provinces, Iran. The data of 19 selected hospitals, two years before after Plan, was collected this cross-sectional study. These included the variables physician nurse number, active beds as inputs bed ...

In this communication we report the electrical characteristics of hexathiapentacene (HTP) and emphasize the unusual chemical structure and molecular packing. We report field-effect mobilities as high as 0.04 cm2 V-1 s-1 and current on/off ratios of >105. With crystallographic evidence of unusually long S-S bonds compared to normal S-S bonds, we have suggested a unique resonance structure simila...

In this paper we describe a microcomputer program (HTP) for predicting the location and orientation of alpha-helical transmembrane segments in integral membrane proteins. HTP is a neural network-based tool which gives as output the protein membrane topology based on the statistical propensity of residues to be located in external and internal loops. This method, which uses single protein sequen...

The intracerebroventricular administration of salmon calcitonin (sCT) to rats induced a dose-dependent increase in the number of head twitches and potentiated such a response elicited by L-5-hydroxytryptophan (L-5-HTP). Subcutaneously administered sCT was ineffective "per se" but could again potentiate the head twitch response elicited by L-5-HTP. Since these data suggest a stimulation of the b...

Although the identification of protein interactions by high-throughput (HTP) methods progresses at a fast pace, 'interactome' data sets still suffer from high rates of false positives and low coverage. To map the human protein interactome, we describe a new framework that uses experimental evidence on structural complexes, the atomic details of binding interfaces and evolutionary conservation. ...

Pretreatment with 5-hydroxytryptophan (5-HTP), a precursor of 5-HT, antagonised while pretreatment with p-chlorophenylalanine (PCPA), a 5-HT depletor, potentiated the myoclonus induced by picrotoxin, a GABA antagonist. Pretreatment with aminooxyacetic acid (AOAA), a GABA transaminase inhibitor, antagonised picrotoxin-induced myoclonus. The combined effect of the least protective doses of AOAA a...

Background: Tariff setting in healthcare is an important control knob affecting the quality, access and cost of services. As part of Iran Health Transformation Plan (HTP) in 2014, the relative value of health care and services was increased to motivate healthcare providers to deliver high quality services. This study aimed to examine the impact of HTP on health services tariffs. Methods: This ...

We have identified a generalized deficiency of monoamine neurotransmitters in a patient with a defect in biopterin synthesis. Neurotransmitter precursors (L-3,4-dihydroxyphenylalanine [L-dopa]; 5-hydroxytryptophan [5-HTP] and a tetrahydropterin [6-methyltetrahydropterin (6MPH4)] were investigated for their ability to normalize monoamine neurotransmitter metabolism. Before treatment, the concent...

Serotonin (5-HT) plays an important role in sensitization of defensive reflexes in Aplysia and is also involved in several aspects of arousal, such as the control of locomotion and of cardiovascular tone. In the preceding paper, we showed that tail-nerve shock, a noxious stimulus that readily induces sensitization, increases the firing rate of a large number of serotonergic neurons throughout t...

Objective: We evaluated the potential population health impact of launching heated tobacco products (HTP) in Japan. Method: use a modeling approach to project effects HTP overall mortality up 2100 and compare those projections against baseline scenario based on smoking rates pre-HTP launch, ie, only. The model was informed using data from publicly available sources literature, including size, y...