The p53 tumor suppressor is an essential barrier against cancer, which is evidenced by loss of p53 activity in the majority of human cancers and unexceptionally early onset of tumors in p53-knockout mice and human Li-Fraumeni syndrome patients. p53 is a sequence-specific transcription factor that regulates gene expression via binding to the consensus p53-responsive element (p53-RE). p53 acts as...

nloaded ection of circulating tumor cells (CTC) is advancing as an effective predictor of patient outcome and eutic response. Unfortunately, our knowledge of CTC biology remains limited, and the impact of treatments on CTC metastatic potential is currently unclear. Improved CTC imaging in vivo and is of free-floating tumor cells now show that cytoskeletal regulation in CTCs contrasts starkly wi...

This paper presents the MIC∗ algebraic structure modelling an environment where autonomous, interacting and mobile entities evolve.

The aim of this study was to determine antimicrobial activities Alchemilla mollis, persica as well ellagic acid and miquelianin against Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans by using microbroth dilution method anti-inflammatory activity human red blood cell (HRBC) membrane stabilization method. Microbroth used...

The antioxidant properties and antimicrobial activity of rosemary extracts were compared to those of vine leaf extracts. The phenolics were quantified by HPLC. Rosemary extracts were stronger in reducing power than vine leaf extracts but possessed weaker superoxide anion radical (O2 ) scavenging capability. The antimicrobial activity was confirmed by the broth microdilution test using minimal i...

The pharmacokinetics and bioavailability of enrofloxacin was compared in Cobb strain broiler chicken after intravenous and oral administration of enrofloxacin at the rate of 10mg.kg -1 . The concentration of enrofloxacin at various time intervals in plasma was determined by HPLC and the pharmacokinetic parameters were calculated by non compartmental approach. AUC was significantly high in i.v. ...

The phytochemical analysis of methanol and chloroform extracts of Umbilicaria cylindrica was determined by HPLC-UV method. The predominant phenolic compound in both extracts was depsidone, salazinic acid (1). Besides salazinic acid, the tested extracts of U. cylindrica contain norstictic acid (2), methyl-β-orcinol carboxylate (3), ethyl haematommate (4), atranorin (5), and usnic acid (6), in di...

AIMS To assess the vitreous penetration of oral levofloxacin (a new fluoroquinolone antibiotic with improved Gram positive activity) in uninflamed phakic eyes. METHODS 15 patients for macula hole surgery were recruited to the study. 10 received a single 500 mg dose of levofloxacin by mouth preoperatively. Five acted as controls. Serum and undiluted vitreous samples were obtained at surgery an...

The purpose of this study was to evaluate the antioxidant and antimicrobial properties of extracts of different fractions of two tomato plant cultivars. The stems, roots, leaves, and whole-plant fractions were evaluated. Tomatine and tomatidine were identified by HPLC-DAD. The leaf extracts from the two varieties showed the highest flavonoids, chlorophyll, carotenoids, and total phenolics conte...