Replication protein-A (RPA) is involved in many processes of DNA metabolism, including DNA replication, repair, and recombination. Cells carrying a mutation in the largest subunit of RPA (rfa1-t11: K45E) have defects in meiotic recombination, mating-type switching, and survival after DNA damage caused by UV and methyl methanesulfonate, as well as increased genome instability; however, this muta...

We investigate the intrinsic noise of a micro-mechanical displacement detector based on the radio-frequency single-electron transistor (rf-SET). Using the noise analysis of a SET by Korotkov as our starting point, we determine the spectral density of the displacement noise due to the tunneling current shot noise. The resulting mechanical displacement noise decreases in inverse proportion to the...

The extraordinary sensitivity of the mammalian ear is commonly attributed to the cochlear amplifier, a cellular process thought to locally boost responses of the cochlear partition to soft sounds. However, cochlear power gain has not been measured directly. Here we use a scanning laser interferometer to determine the volume displacement and volume velocity of the cochlear partition by measuring...

Biconical tapered single-mode fiber, which is common in many telecommunications components, offers an alternative sensor to typical optical fiber strain gauges that are susceptible to temperature and pressure effects and require expensive and sophisticated signal acquisition systems. Cavity ringdown spectroscopy, a technique commonly applied to high-sensitivity chemical analysis, offers detecti...

We investigate the tunneling shot noise limits on the sensitivity of a microme-chanical displacement detector based on a metal junction, radio-frequency single-electron transistor (rf-SET). In contrast with the charge sensitivity of the rf-SET electrometer, the displacement sensitivity improves with increasing gate voltage bias and, with a suitably optimized rf-SET, displacement sensitivities o...

in this paper, using numerical methods and test results, the behavior of reinforced concrete beams strengthened with fiber-reinforced polymers (frp) is investigated. in the numerical analysis, the concrete damaged plasticity model is used for considering the nonlinear behavior and strain softening of concrete. the abaqus finite element program is utilized for the analysis of 12 flexural beams s...

Global sensitivity indices play important roles in global sensitivity analysis based on ANOVA high-dimensional model representation. However, few effective methods are available for the estimation of the indices when the objective function is a nonparametric model. In this paper, we explore the estimation of global sensitivity indices of non-parametric models. The main result (Theorem 2.1) show...

[1] The 2006 Mw7.0 Mozambique (Machaze) normal-faulting earthquake ruptured an unusually steeply dipping fault plane ( 75°). The amount of slip in the earthquake decreased from depths of 10 km toward the surface, and this shallow slip deficit was at least partly recovered by postseismic afterslip on the shallow part of the fault plane. An adjacent normal fault segment slipped postseismically (a...