DNA replication stress has been implicated in the etiology of genetic diseases, including cancers. It has been proposed that genomic sites that inhibit or slow DNA replication fork progression possess recombination hotspot activity and can form potential fragile sites. Here we used the fission yeast, Schizosaccharomyces pombe, to demonstrate that hotspot activity is not a universal feature of r...

Distributed Virtual Environment (DVE) topology management and message propagation schemes have been proposed for many years. Evaluating DVE message propagation schemes requires a variety of assumptions whose verity significantly affects results, such as details about avatar movement characteristics. We implemented two schemes for waypoint and hotspot detection, and examined their applicability ...

Modern Java Compilers, such as Sun’s HotSpot compilers, implement a number of optimizations, ranging from high-level program transformations to low-level architecure dependent operations such as instruction scheduling. In a Just-in-Time (JIT) environment, the impact of each optimization must be weighed against its cost in terms of total runtime. Towards better understanding the usefulness of in...