In this work, a series of arylpiperazine derivatives were synthesized and screened by in vivo pharmacological trials. Among the tested compounds, 2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)-1-phenylethanone (18) and 2-(4-(2,3-dimethylphenyl)piperazin-1-yl)-1-phenylethanone (19) exhibited potent analgesic activities in both the mice writhing and mice hot plate tests. They showed more than 70...

Results: On the hot plate model ED50 value was per body weight 0.34 (0.18 0.63) mg/kg of the pyrodazol /i.g, 1.00 (0.59 1.70) mg/kg/of the ketorolac/ i. g. in 90 minutes post administration. On the hot plate model in 0.3 1.3 mg/kg/doses i.m the pirodazol is similar to morphine hydrochloride in dose 2.5 mg/kg i.m. On the tail-flick model ED50 values of the pyrodazol and ketorolac are 1.9 (1.12 3...

Tricyclic antidepressant drugs induce antinociceptive effect and suggest that their analgesic action could be related to the monoaminergic activity of the drugs. The analgesic activity of amitriptyline was observed in mouse models of acute pain. Mice were divided into different groups and were given amitriptyline in different doses alone and in combination with morphine. Reaction time in Hot-Pl...

Kim, M.H., Kim, S.M., Kim, C.S., Park, S.J., Lee, C.H. and Rhee, J.Y. 2002. Quality of Korean ginseng dried by a prototype continuous flow dryer using far infrared radiation and hot air. Canadian Biosystems Engineering/Le génie des biosystèmes au Canada 44: 3.473.54. This study was performed to examine the effects of infrared (IR)/hot-air combination drying on some quality attributes of Korean ...

Welded beam-to-column connections of high-rise steel structures are susceptive to fatigue damage under wind loading. However, most fatigue assessments in the field of civil engineering are mainly based on nominal stress or hot spot stress theories, which has the disadvantage of dependence on the meshing styles and massive curves selected. To address this problem, in this paper, the equivalent s...

existence of cracks in industrial structures is one of the important causes of their failure, especially when they are subjected to important axial compressive forces that might lead to buckling. therefore, it must be considered in stress analysis and designing and loading of such structures. in this paper, the buckling and post-buckling behaviors of stainless-steel cracked plates under axial c...

This paper presents an integrated high temperature ultrasonic transducer (HTUT) on a sensor insert and its application for real-time diagnostics of the conventional hot embossing process to fabricate V-cut patterns. The sensor was directly deposited onto the sensor insert of the hot embossing mold by using a sol-gel spray technique. It could operate at temperatures higher than 400 °C and uses a...