Article history: Received on: 12/06/2013 Revised on: 16/09/2013 Accepted on: 17/10/2013 Available online: 31/10/2013 Tuberculosis has metamorphosized over the decades from drug resistant to multidrug resistant to the lethal extensively drug resistant forms lately. With scarce newer anti-TB drugs emerging, there is a pressing need to ameliorate the current treatment therapy by modulating the for...

The aim of this study was to evaluate hot-melt extrusion (HME) as a continuous process to form cyclodextrin (CD) inclusion complexes in order to increase the solubility and dissolution rate of itraconazole (ITZ), a class II model drug molecule of the Biopharmaceutics Classification System. Different CD derivatives were tested in a 1:1 (CD:ITZ) molar ratio to obtain CD ternary inclusion complexe...

The main aim of the research focused on the production of hot-melt extrusion (HME) formulations with increased dissolution properties of albendazole (ABZ). Therefore, HME was applied as a continuous manufacturing technique to produce amorphous solid dispersions of the poorly water soluble drug ABZ combined with the polymer matrix polyvinylpyrrolidone PVP K12. HME formulations of ABZ-PVP K12 com...

The production rate of polymer fibers by extrusion is usually limited by the appearance of a series of instabilities ("melt fracture") that lead to unwanted undulations of the surface. We present both qualitative and quantitative experimental evidence that-in addition to previously known polymer-specific scenarios-there is an intrinsic route towards melt fracture type phenomena: a nonlinear ("s...

Many fabrication processes for polymeric objects include melt extrusion, in which the molten polymer is conveyed by a ram or a screw and the melt is then forced through a shaping die in continuous processing or into a mold for the manufacture of discrete molded parts. The properties of the fabricated solid object, including morphology developed during cooling and solidification, depend in part ...